For decades, we have observed a major biodiversity crisis impacting all taxa. Avian species
have been particularly well monitored over the long term, documenting their declines. In …

The alpha2ß1 integrin is a major collagen receptor that plays an essential role in the adhesion
of normal and tumor cells to the extracellular matrix. Alternagin-C (ALT-C), a disintegrin-…

… After 2.5-h incubation at 20 C and washing three times with binding buffer, the cells were
treated with 0.3 ml of 0.5 M NaOH for 30 min. The radioactivity contained in each cell lysate was …

Matrix metalloproteinases (MMPs) play an important role in cancer metastasis. Here, we
investigated the effect of fibroblast growth factor-2 (FGF-2) and 12-O-tetradecanoylphorbol-13-…

… 0.5 M NaCl, 20 mM imidazol and 6 M urea) and 4 column volumes of buffer D (40 mM Tris–HCl,
pH 7.9, 0.5 M NaCl, 1 M imidazole and 6 M … against 25 volumes of 3 M urea in water and …

Although metastatic spread is the most frequent cause of death in cancer patients, there are
very few drugs specifically targeting this process. Bases for a new antimetastatic drug …

Constitutional epimutations of DNA mismatch repair (MMR) genes have been recently reported
as a possible cause of Lynch syndrome. However, little is known about their prevalence, …

Colorectal cancers (CRC) with microsatellite instability (MSI) display unique clinicopathologic
features including a mucinous pattern with frequent expression of the secreted mucins …

Polyphenols extracted from many plants have shown antiproliferative and antitumor activities
in a wide range of carcinogenesis models. The antiproliferative effects of polyphenols …

… The molar concentration (M) of the siRNAs was equal to the concentration of siRNA/14 in
μg assuming that 1 nmol of an average 21-mer double strand (ds)RNA contained 14 μg RNA. …