User profiles for LUCA PORCU

Luca Porcu

IRCCS - Istituto di Ricerche Farmacologiche Mario Negri
Verified email at marionegri.it
Cited by 2958

Antibody–Fc/FcR interaction on macrophages as a mechanism for hyperprogressive disease in non–small cell lung cancer subsequent to PD-1/PD-L1 blockade

…, P Gasparini, V Huber, M Milione, L Porcu… - Clinical Cancer …, 2019 - AACR
Purpose: Hyperprogression (HP), a paradoxical boost in tumor growth, was described in a
subset of patients treated with immune checkpoint inhibitors (ICI). Neither clinicopathologic …

A phase 2 single-arm study of cabozantinib in patients with advanced or unresectable renal cell carcinoma pretreated with one immune checkpoint inhibitor: The …

G Procopio, M Claps, C Pircher, L Porcu, P Sepe… - 2021 - ascopubs.org
4569 Background: For many years, vascular endothelial growth factor (VEGF)-targeted therapy
(tp) has been a milestone for metastatic renal cell carcinoma (mRCC). Recently, first line …

[HTML][HTML] Resistance to platinum-based chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer

…, R Fruscio, L Clivio, L Beltrame, L Porcu… - European journal of …, 2013 - Elsevier
BACKGROUND: The present study is aimed to identify genetic pathways correlated with
chemoresistance in epithelial ovarian cancer (EOC). METHODS: We compared the molecular …

[HTML][HTML] Does surgery improve survival of patients with malignant pleural mesothelioma?: a multicenter retrospective analysis of 1365 consecutive patients

…, G Garofalo, AV Bedini, M Garassino, L Porcu… - Journal of Thoracic …, 2014 - Elsevier
Background: Surgery with pleurectomy/decortication (P/D) or extrapleural pneumonectomy (EPP)
can be an option for selected patients with resectable malignant pleural mesothelioma …

HER2 positivity predicts unresponsiveness to EGFR‐targeted treatment in metastatic colorectal cancer

A Sartore‐Bianchi, A Amatu, L Porcu, S Ghezzi… - The …, 2019 - academic.oup.com
Background HER2 amplification is detected in 3% of patients with colorectal cancer (CRC),
making tumors in the metastatic setting vulnerable to double pharmacological HER2 …

[HTML][HTML] Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

…, GJ Sills, A Jorgensen, L Porcu… - The Journal of …, 2017 - Am Soc Clin Investig
Approximately 30% of epilepsy patients do not respond to antiepileptic drugs, representing
an unmet medical need. There is evidence that neuroinflammation plays a pathogenic role in …

Multimodal study of default‐mode network integrity in disorders of consciousness

…, S Ferraro, D Rossi Sebastiano, L Porcu… - Annals of …, 2016 - Wiley Online Library
Objective Understanding residual brain function in disorders of consciousness poses
extraordinary challenges, and imaging examinations are needed to complement clinical …

n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis

…, C Vandenplas, K Leclercq, E Aronica, L Porcu… - Brain, 2018 - academic.oup.com
Epilepsy therapy is based on drugs that treat the symptoms rather than the underlying
mechanisms of the disease (epileptogenesis). There are no treatments for preventing seizures or …

Sacral chordoma: long-term outcome of a large series of patients surgically treated at two reference centers

…, E Palmerini, P Collini, M Gambarotti, L Porcu… - Spine, 2016 - journals.lww.com
Study Design. Retrospective case series. Objective. To report on the natural history and long-term
outcome of a large series of consecutive primary sacral chordoma patients surgically …

[HTML][HTML] Outcomes on safety and efficacy of left atrial appendage occlusion in end stage renal disease patients undergoing dialysis

S Genovesi, L Porcu, G Slaviero, G Casu, S Bertoli… - Journal of …, 2021 - Springer
Background In patients with end stage renal disease and atrial fibrillation (AF), undergoing
chronic dialysis, direct oral agents are contraindicated and warfarin does not fully prevent …