Vitamin D and human health: lessons from vitamin D receptor null mice

R Bouillon, G Carmeliet, L Verlinden… - Endocrine …, 2008 - academic.oup.com
The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise
mode of action and the full spectrum of activities of the vitamin D hormone, 1,25-…

Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects

…, P Dhawan, A Verstuyf, L Verlinden… - Physiological …, 2016 - journals.physiology.org
1,25-Dihydroxvitamin D 3 [1,25(OH) 2 D 3 ] is the hormonally active form of vitamin D. The
genomic mechanism of 1,25(OH) 2 D 3 action involves the direct binding of the 1,25(OH) 2 D 3 …

Vitamin D and cancer

R Bouillon, G Eelen, L Verlinden, C Mathieu… - The Journal of steroid …, 2006 - Elsevier
1,25-dihydroxy Vitamin D [1,25-(OH) 2 D] exerts its effects via the vitamin D receptor (VDR)
that belongs to the steroid/thyroid hormone receptor superfamily leading to gene regulation …

Immune Regulation of 25‐Hydroxyvitamin‐D3‐1α‐Hydroxylase in Human Monocytes

…, L Overbergh, A Giulietti, L Verlinden… - Journal of Bone and …, 2006 - academic.oup.com
Monocytes express 1α‐hydroxylase, the enzyme responsible for final hydroxylation of
vitamin D 3 , in response to IFNγ and CD14/TLR4 activation. Cross‐talk between the JAK‐STAT, …

The vitamin D receptor gene FokI polymorphism: Functional impact on the immune system

E van Etten, L Verlinden, A Giulietti… - European journal of …, 2007 - Wiley Online Library
1α,25‐Dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) has important effects on the growth and function
of multiple cell types. These pleiotropic effects of 1,25(OH) 2 D 3 are mediated through …

[PDF][PDF] Vitamin D3 induces tolerance in human dendritic cells by activation of intracellular metabolic pathways

…, ACF Gutierrez, L Van Lommel, K Marchal, L Verlinden… - Cell reports, 2015 - cell.com
Metabolic switches in various immune cell subsets enforce phenotype and function. In the
present study, we demonstrate that the active form of vitamin D, 1,25-dihydroxyvitamin D 3 (1,…

[HTML][HTML] The future of vitamin D analogs

C Leyssens, L Verlinden, A Verstuyf - Frontiers in physiology, 2014 - frontiersin.org
The active form of vitamin D 3 , 1,25-dihydroxyvitamin D 3 , is a major regulator of bone and
calcium homeostasis. In addition, this hormone also inhibits the proliferation and stimulates …

Action of 1, 25 (OH) 2D3 on the cell cycle genes, cyclin D1, p21 and p27 in MCF-7 cells

L Verlinden, A Verstuyf, R Convents, S Marcelis… - Molecular and cellular …, 1998 - Elsevier
1,25(OH) 2 D 3 is a known growth inhibitor and differentiation inducer of several cancer cell
lines. To establish the molecular mechanism of 1,25(OH) 2 D 3 as an antiproliferating agent, …

The E2F-Regulated Gene Chk1 Is Highly Expressed in Triple-Negative Estrogen Receptor−/Progesterone Receptor−/HER-2− Breast Carcinomas

L Verlinden, I Vanden Bempt, G Eelen, M Drijkoningen… - Cancer research, 2007 - AACR
We previously showed that checkpoint kinase 1 (Chk1) and Claspin, two DNA-damage
checkpoint proteins, were down-regulated by 1,25-dihydroxyvitamin D 3 , a known inhibitor of …

Vitamin D status at breast cancer diagnosis: correlation with tumor characteristics, disease outcome, and genetic determinants of vitamin D insufficiency

…, G Peuteman, A Laenen, L Verlinden… - …, 2012 - academic.oup.com
We correlated serum 25-hydroxyvitamin D 3 (25OHD) levels with tumor characteristics and
clinical disease outcome in breast cancer patients and assessed the impact of genetic …