Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
…, Y Kawakami, K Arihiro, H Ohdan, K Gotoh… - Nature …, 2012 - nature.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death
worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were …
worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were …
Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer
…, H Taniguchi, Y Kawakami, M Ueno, K Gotoh… - Nature …, 2016 - nature.com
Liver cancer, which is most often associated with virus infection, is prevalent worldwide, and
its underlying etiology and genomic structure are heterogeneous. Here we provide a whole-…
its underlying etiology and genomic structure are heterogeneous. Here we provide a whole-…
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury
Neonatal hypoxic/ischemic (H/I) brain injury causes neurological impairment, including
cognitive and motor dysfunction as well as seizures. However, the molecular mechanisms …
cognitive and motor dysfunction as well as seizures. However, the molecular mechanisms …
A novel image‐guided surgery of hepatocellular carcinoma by indocyanine green fluorescence imaging navigation
K Gotoh, T Yamada, O Ishikawa… - Journal of surgical …, 2009 - Wiley Online Library
Background and Objectives The clear delineation between tumor and normal tissue is ideal
for real‐time surgical navigation imaging. We present a novel indocyanine green (ICG) …
for real‐time surgical navigation imaging. We present a novel indocyanine green (ICG) …
[HTML][HTML] Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations
…, Y Kawakami, H Aikata, M Ueno, S Hayami, K Gotoh… - Journal of …, 2018 - Elsevier
Background & Aims Biliary tract cancers (BTCs) are clinically and pathologically heterogeneous
and respond poorly to treatment. Genomic profiling can offer a clearer understanding of …
and respond poorly to treatment. Genomic profiling can offer a clearer understanding of …
Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial
…, K Shimada, Y Takahashi, T Nakagohri, K Gotoh… - The Lancet, 2023 - thelancet.com
Background S-1 has shown promising efficacy with a mild toxicity profile in patients with
advanced biliary tract cancer. The aim of this study was to evaluate whether adjuvant S-1 …
advanced biliary tract cancer. The aim of this study was to evaluate whether adjuvant S-1 …
[HTML][HTML] MicroRNA-155 controls exosome synthesis and promotes gemcitabine resistance in pancreatic ductal adenocarcinoma
…, T Asaoka, T Noda, H Wada, K Kawamoto, K Gotoh… - Scientific reports, 2017 - nature.com
The cancer drug gemcitabine (GEM) is a key drug for treating pancreatic ductal adenocarcinoma
(PDAC), but PDAC cells develop chemoresistance after long-term administration. Since …
(PDAC), but PDAC cells develop chemoresistance after long-term administration. Since …
Hepatocellular carcinoma arising from non-cirrhotic nonalcoholic steatohepatitis
…, C Tamai, R Ishihara, T Matsunaga, K Gotoh… - Journal of …, 2009 - Springer
Purpose Characteristics of hepatocellular carcinoma (HCC) complicating nonalcoholic
steatohepatitis (NASH) are still controversial. Most NASH related HCCs are believed to develop …
steatohepatitis (NASH) are still controversial. Most NASH related HCCs are believed to develop …
LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers
…, M Yamasaki, I Sohma, K Gotoh… - International …, 2008 - spandidos-publications.com
Autophagy is a bulk protein and organelle degradation process essential for cell maintenance
and viability. Microtubule-associated protein 1 light chain 3 (LC3), the mammalian …
and viability. Microtubule-associated protein 1 light chain 3 (LC3), the mammalian …
[HTML][HTML] Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity
Intrahepatic cholangiocarcinoma and combined hepatocellular cholangiocarcinoma show
varying degrees of biliary epithelial differentiation, which can be defined as liver cancer …
varying degrees of biliary epithelial differentiation, which can be defined as liver cancer …