Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles

…, R Suzuki, K Murakami, H Aizaki, K Ishii… - Journal of …, 2008 - Am Soc Microbiol
Nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) possesses multiple and diverse
functions in RNA replication, interferon resistance, and viral pathogenesis. Recent studies …

A 32-bit PowerPC system-on-a-chip with support for dynamic voltage scaling and dynamic frequency scaling

…, HC Ngo, BC Brock, KI Ishii… - IEEE Journal of Solid …, 2002 - ieeexplore.ieee.org
A PowerPC system-on-a-chip processor which makes use of dynamic voltage scaling and
on-the-fly frequency scaling to adapt to the dynamically changing performance demands and …

The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon‐γ and interleukin‐17 production by human CD4+ T cells

…, M Ohishi, H Miyahara, S Tanaka, K Ishii… - Arthritis & …, 2012 - Wiley Online Library
Objective Tofacitinib (CP‐690,550) is a novel JAK inhibitor that is currently in clinical trials
for the treatment of rheumatoid arthritis (RA). The aim of this study was to examine the effects …

Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors

I Shoji, H Aizaki, H Tani, K Ishii… - Journal of General …, 1997 - microbiologyresearch.org
A baculovirus (Autographa californica nucleopoly- hedrovirus) vector containing a strong
promoter, the CAG promoter, was developed to introduce foreign genes into mammalian cells. …

Epidermal growth factor receptor is a host-entry cofactor triggering hepatitis B virus internalization

…, W Saso, R Sugiyama, K Ishii… - Proceedings of the …, 2019 - National Acad Sciences
Sodium taurocholate cotransporting polypeptide (NTCP) is a host cell receptor required for
hepatitis B virus (HBV) entry. However, the susceptibility of NTCP-expressing cells to HBV is …

Hepatitis C viral life cycle

T Suzuki, K Ishii, H Aizaki, T Wakita - Advanced drug delivery reviews, 2007 - Elsevier
Hepatitis C virus (HCV) has been recognized as a major cause of chronic liver diseases
worldwide. Molecular studies of the virus became possible with the successful cloning of its …

Noroviruses distinguish between type 1 and type 2 histo-blood group antigens for binding

…, Z Xiaofan, T Miyamura, T Wakita, K Ishii… - Journal of …, 2008 - Am Soc Microbiol
Norovirus (NoV) is a causative agent of acute gastroenteritis. NoV binds to histo-blood group
antigens (HBGAs), namely, ABH antigens and Lewis (Le) antigens, in which type 1 and …

Characterization of pseudotype VSV possessing HCV envelope proteins

…, T Kimura-Someya, R Suzuki, H Aizaki, K Ishii… - Virology, 2001 - Elsevier
The genome of hepatitis C virus (HCV) encodes two envelope glycoproteins (E1 and E2),
which are thought to be responsible for receptor binding and membrane fusion resulting in …

A subcutaneously injected UV-inactivated SARS coronavirus vaccine elicits systemic humoral immunity in mice

…, M Kasai, S Morikawa, S Itamura, K Ishii… - International …, 2004 - academic.oup.com
The recent emergence of severe acute respiratory syndrome (SARS) was caused by a
novel coronavirus, SARS-CoV. It spread rapidly to many countries and developing a SARS …

Risk prediction modeling based on a combination of initial serum biomarker levels in polymyositis/dermatomyositis–associated interstitial lung disease

…, Y Yoshioka, T Hirai, Y Wada, K Ishii… - Arthritis & …, 2021 - Wiley Online Library
Objective To establish predictive models for mortality in patients with polymyositis/dermatomyositis–associated
interstitial lung disease (PM/DM‐ILD) using a combination of initial serum …