By using a plasmid-based transient protein expression system in cultured cells and an in
vitro transcription/translation system, we analyzed the proteolytic processing of the putative …

Hepatitis C virus produces about 12 viral proteins by proteolytic cleavage of the viral polyprotein
precursor produced from the largest open reading frame in the viral genome. We have …

Background The Controlling Nutritional Status (CONUT) score is an objective tool that is
widely used to assess the nutritional status in patients, including those with cancer. The …

Background & Aims The microvascular invasion of cancer cells (mvi) is a good prognostic
factor after hepatic resection ( HR ) and liver transplantation for hepatocellular carcinoma ( …

We propose a novel method for solving optimal sensor placement problem for high-dimensional
system using an annealing machine. The sensor points are calculated as a maximum …

We previously showed that two proteins, a 56-kDa protein (p56) and a 58-kDa protein (p58),
are produced from the hepatitis C virus (HCV) nonstructural 5A region (NS5A) and that the …

Processing of the boundary region between the putative structural and nonstructural regions
of the hepatitis C virus precursor polyprotein was analyzed by in vitro translation using …

Background In Japan, several large healthcare databases have become available for
research since the early 2000’s. However, validation studies to examine the accuracy of these …

Background and Aim The C‐reactive protein (CRP)/albumin (Alb) ratio has been reported as
a novel prognostic marker in several cancers. The objective of this study was to investigate …

Background: The ratio of early diastolic transmitral flow velocity (E) to tissue Doppler (TD)
mitral annular early diastolic velocity (E/E′ VEL‐TD ) has been widely used for the …