User profiles for KLAUS PANTEL
Klaus PantelProfessor der Medizin Verified email at uke.de Cited by 88973 |
Tumour exosome integrins determine organotropic metastasis
Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one
of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human …
of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human …
Challenges in circulating tumour cell research
C Alix-Panabières, K Pantel - Nature Reviews Cancer, 2014 - nature.com
During the past ten years, circulating tumour cells (CTCs) have received enormous attention
as new biomarkers and the subject of basic research. Although CTCs are already used in …
as new biomarkers and the subject of basic research. Although CTCs are already used in …
Dissecting the metastatic cascade
K Pantel, RH Brakenhoff - Nature reviews cancer, 2004 - nature.com
Despite recent progress in gene-expression profiling studies, the biology underlying the
various patterns of metastasis that are observed in different tumour types remains unclear. The …
various patterns of metastasis that are observed in different tumour types remains unclear. The …
Circulating tumor cells: liquid biopsy of cancer
C Alix-Panabières, K Pantel - Clinical chemistry, 2013 - academic.oup.com
BACKGROUND The detection and molecular characterization of circulating tumor cells (CTCs)
are one of the most active areas of translational cancer research, with >400 clinical …
are one of the most active areas of translational cancer research, with >400 clinical …
Cell-free nucleic acids as biomarkers in cancer patients
DNA, mRNA and microRNA are released and circulate in the blood of cancer patients. Changes
in the levels of circulating nucleic acids have been associated with tumour burden and …
in the levels of circulating nucleic acids have been associated with tumour burden and …
[HTML][HTML] Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer
Background Cytokeratins are specific markers of epithelial cancer cells in bone marrow. We
assessed the influence of cytokeratin-positive micrometastases in the bone marrow on the …
assessed the influence of cytokeratin-positive micrometastases in the bone marrow on the …
Liquid biopsy: from discovery to clinical application
C Alix-Panabières, K Pantel - Cancer discovery, 2021 - AACR
The analysis of blood for CTCs or cell-free nucleic acids called “liquid biopsy” has opened
new avenues for cancer diagnostics, including early detection of tumors, improved risk …
new avenues for cancer diagnostics, including early detection of tumors, improved risk …
[HTML][HTML] A pooled analysis of bone marrow micrometastasis in breast cancer
…, J Bliss, A Vincent-Salomon, K Pantel - New England journal …, 2005 - Mass Medical Soc
Background We assessed the prognostic significance of the presence of micrometastasis in
the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis. …
the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis. …
In vitro differentiation of endothelial cells from AC133-positive progenitor cells
…, U Schumacher, C Wagener, K Pantel… - Blood, The Journal …, 2000 - ashpublications.org
Recent findings support the hypothesis that the CD34 + -cell population in bone marrow and
peripheral blood contains hematopoietic and endothelial progenitor and stem cells. In this …
peripheral blood contains hematopoietic and endothelial progenitor and stem cells. In this …
Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system
…, S Jackson, T Gornet, M Cristofanilli, K Pantel - Clinical cancer …, 2007 - AACR
Purpose: The CellSearch system (Veridex, Warren, NJ) is designed to enrich and enumerate
circulating tumor cells (CTCs) from peripheral blood. Here, we validated the analytic …
circulating tumor cells (CTCs) from peripheral blood. Here, we validated the analytic …