User profiles for KLAUS PANTEL

Klaus Pantel

Professor der Medizin
Verified email at uke.de
Cited by 88973

Tumour exosome integrins determine organotropic metastasis

…, MS Brady, O Fodstad, V Muller, K Pantel… - Nature, 2015 - nature.com
Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one
of cancer’s greatest mysteries. Here we demonstrate that exosomes from mouse and human …

Challenges in circulating tumour cell research

C Alix-Panabières, K Pantel - Nature Reviews Cancer, 2014 - nature.com
During the past ten years, circulating tumour cells (CTCs) have received enormous attention
as new biomarkers and the subject of basic research. Although CTCs are already used in …

Dissecting the metastatic cascade

K Pantel, RH Brakenhoff - Nature reviews cancer, 2004 - nature.com
Despite recent progress in gene-expression profiling studies, the biology underlying the
various patterns of metastasis that are observed in different tumour types remains unclear. The …

Circulating tumor cells: liquid biopsy of cancer

C Alix-Panabières, K Pantel - Clinical chemistry, 2013 - academic.oup.com
BACKGROUND The detection and molecular characterization of circulating tumor cells (CTCs)
are one of the most active areas of translational cancer research, with >400 clinical …

Cell-free nucleic acids as biomarkers in cancer patients

H Schwarzenbach, DSB Hoon, K Pantel - Nature Reviews Cancer, 2011 - nature.com
DNA, mRNA and microRNA are released and circulate in the blood of cancer patients. Changes
in the levels of circulating nucleic acids have been associated with tumour burden and …

[HTML][HTML] Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer

S Braun, K Pantel, P Müller, W Janni… - New England journal …, 2000 - Mass Medical Soc
Background Cytokeratins are specific markers of epithelial cancer cells in bone marrow. We
assessed the influence of cytokeratin-positive micrometastases in the bone marrow on the …

Liquid biopsy: from discovery to clinical application

C Alix-Panabières, K Pantel - Cancer discovery, 2021 - AACR
The analysis of blood for CTCs or cell-free nucleic acids called “liquid biopsy” has opened
new avenues for cancer diagnostics, including early detection of tumors, improved risk …

[HTML][HTML] A pooled analysis of bone marrow micrometastasis in breast cancer

…, J Bliss, A Vincent-Salomon, K Pantel - New England journal …, 2005 - Mass Medical Soc
Background We assessed the prognostic significance of the presence of micrometastasis in
the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis. …

In vitro differentiation of endothelial cells from AC133-positive progenitor cells

…, U Schumacher, C Wagener, K Pantel… - Blood, The Journal …, 2000 - ashpublications.org
Recent findings support the hypothesis that the CD34 + -cell population in bone marrow and
peripheral blood contains hematopoietic and endothelial progenitor and stem cells. In this …

Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system

…, S Jackson, T Gornet, M Cristofanilli, K Pantel - Clinical cancer …, 2007 - AACR
Purpose: The CellSearch system (Veridex, Warren, NJ) is designed to enrich and enumerate
circulating tumor cells (CTCs) from peripheral blood. Here, we validated the analytic …