Sinoatrial Node Dysfunction and Early Unexpected Death of Mice With a Defect of klotho Gene Expression

…, H Tsujikawa, K Yasui, JK Lee, K Kamiya, K Kitaichi… - Circulation, 2004 - Am Heart Assoc
Background— Homozygous mutant mice with a defect of klotho gene expression (kl/kl) show
multiple age-related disorders and premature death from unknown causes. Methods and …

Role of tumor necrosis factor-α in methamphetamine-induced drug dependence and neurotoxicity

…, MH Tran, A Seto, M Yoshimura, K Kitaichi… - Journal of …, 2004 - Soc Neuroscience
Tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, is now emerging as an
important modulator of the function of the CNS. Methamphetamine (METH) is a widely abused …

Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine

L Zhang, K Kitaichi, Y Fujimoto, H Nakayama… - Progress in Neuro …, 2006 - Elsevier
The effects of minocycline on behavioral changes and neurotoxicity in the dopaminergic
neurons induced by the administration of methamphetamine (METH) were studied. …

Continuous positive airway pressure improves daytime baroreflex sensitivity and nitric oxide production in patients with moderate to severe obstructive sleep apnea …

A Noda, S Nakata, Y Koike, S Miyata, K Kitaichi… - Hypertension …, 2007 - nature.com
Individuals with obstructive sleep apnea syndrome (OSAS) are at high risk for cardiovascular
morbidity and mortality. The effects of OSAS severity and nocturnal continuous positive …

Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin

…, S Torita, M Nadai, K Baba, K Kitaichi… - Antimicrobial agents …, 2004 - Am Soc Microbiol
P glycoprotein and multidrug resistance-associated protein 2 (Mrp2), ATP-dependent
membrane transporters, exist in a variety of normal tissues and play important roles in the …

A multi-institutional study analyzing effect of prophylactic medication for prevention of opioid-induced gastrointestinal dysfunction

…, H Matsunaga, K Suemaru, K Kitaichi… - The Clinical journal …, 2012 - journals.lww.com
Objectives: The aim of this study was to evaluate the effectiveness of prophylactic treatment
with laxatives and antiemetics on the incidence of gastrointestinal adverse reactions such as …

Expression of the purported sigma1 (σ1) receptor in the mammalian brain and its possible relevance in deficits induced by antagonism of the NMDA receptor complex …

K Kitaichi, JG Chabot, FF Moebius, A Flandorfer… - Journal of chemical …, 2000 - Elsevier
Sigma (σ) receptors have generated a great deal of interest on the basis of their possible
role in psychosis, neuroprotection and various other behaviors including learning processes. …

Methamphetamine‐induced dopaminergic neurotoxicity is regulated by quinone formation‐related molecules

…, FJ Diaz‐Corrales, M Fukuda, K Kitaichi… - The FASEB …, 2006 - Wiley Online Library
Recently, the neurotoxicity of dopamine (DA) quinone formation by auto‐oxidation of DA
has focused on dopaminergic neuron‐specific oxidative stress. In the present study, we …

[HTML][HTML] Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine

JY Ip, M Sone, C Nashiki, Q Pan, K Kitaichi, K Yanaka… - Scientific reports, 2016 - nature.com
The long noncoding RNA Gomafu/MIAT/Rncr2 is thought to function in retinal cell specification,
stem cell differentiation and the control of alternative splicing. To further investigate …

The evaluation of risk factors associated with adverse drug reactions by metformin in type 2 diabetes mellitus

S Okayasu, K Kitaichi, A Hori, T Suwa… - Biological and …, 2012 - jstage.jst.go.jp
Metformin is a drug to improve glycemic control by reducing insulin resistance and is currently
considered to be one of the first-choice drugs for type 2 diabetes mellitus (T2DM). However…