Curcumin attenuates DNB-induced murine colitis
B Salh, K Assi, V Templeman… - American journal …, 2003 - journals.physiology.org
Numerous therapies used for inflammatory bowel disease (IBD) target the transcription
factor NF-κB, which is involved in the production of cytokines and chemokines integral for …
factor NF-κB, which is involved in the production of cytokines and chemokines integral for …
The specific JNK inhibitor SP600125 targets tumour necrosis factor‐α production and epithelial cell apoptosis in acute murine colitis
K Assi, R Pillai, A Gómez‐Muñoz, D Owen… - Immunology, 2006 - Wiley Online Library
Stress‐activated protein kinases (SAPKs) are activated in human inflammatory bowel disease
(IBD). Recently it has been demonstrated that p38MAPK (mitogen‐activated protein kinase…
(IBD). Recently it has been demonstrated that p38MAPK (mitogen‐activated protein kinase…
Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells
M Moussavi, K Assi, A Gómez-Muñoz, B Salh - Carcinogenesis, 2006 - academic.oup.com
A wealth of evidence supports the notion that curcumin, a phytochemical present in turmeric,
is a potent chemopreventive agent for colon cancer. Its mechanism of action remains …
is a potent chemopreventive agent for colon cancer. Its mechanism of action remains …
Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells
SJ Patterson, JM Han, R Garcia, K Assi… - The Journal of …, 2011 - journals.aai.org
Regulatory T cells (Tregs) have a reduced capacity to activate the PI3K/Akt pathway downstream
of the TCR, and the resulting low activity of Akt is necessary for their development and …
of the TCR, and the resulting low activity of Akt is necessary for their development and …
The importance of integrin‐linked kinase in the regulation of bladder cancer invasion
Y Matsui, K Assi, O Ogawa, PA Raven… - … journal of cancer, 2012 - Wiley Online Library
It is important to understand the molecular mechanisms of bladder cancer progression not
only to prevent cancer progression but also to detect new therapeutic targets against …
only to prevent cancer progression but also to detect new therapeutic targets against …
Integrin-linked kinase regulates cell proliferation and tumour growth in murine colitis-associated carcinogenesis
K Assi, J Mills, D Owen, C Ong, R St Arnaud, S Dedhar… - Gut, 2008 - gut.bmj.com
Background: Integrins are transmembrane cell surface receptors that mediate cell–cell and
cell–matrix contacts. Integrin-linked kinase (ILK) is the binding partner of β1 and β3 integrins, …
cell–matrix contacts. Integrin-linked kinase (ILK) is the binding partner of β1 and β3 integrins, …
Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic …
DF Schaeffer, K Assi, K Chan, AK Buczkowski… - Virchows Archiv, 2010 - Springer
Integrin-linked kinase (ILK) is a key molecule involved in mediating several biological functions
including cell-matrix interactions, angiogenesis, and invasion, as well as playing a role in …
including cell-matrix interactions, angiogenesis, and invasion, as well as playing a role in …
[HTML][HTML] Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire
K Assi, S Patterson, S Dedhar, D Owen, M Levings… - BMC immunology, 2011 - Springer
Background The role of integrin signaling in mucosal inflammation is presently unknown.
Hence, we aimed to investigate the role of epithelial-derived integrin-linked kinase (ILK), a …
Hence, we aimed to investigate the role of epithelial-derived integrin-linked kinase (ILK), a …
The single IgG IL-1–related receptor controls TLR responses in differentiated human intestinal epithelial cells
…, HP Sham, KS Bergstrom, JT Huang, K Assi… - The Journal of …, 2010 - journals.aai.org
Intestinal epithelial cells (IECs) are constantly exposed to enteric microbes. Although IECs
express TLRs that recognize bacterial products, the activation of these TLRs is strictly …
express TLRs that recognize bacterial products, the activation of these TLRs is strictly …
[HTML][HTML] Integrin-linked kinase links dynactin-1/dynactin-2 with cortical integrin receptors to orient the mitotic spindle relative to the substratum
EJ Morris, K Assi, B Salh, S Dedhar - Scientific reports, 2015 - nature.com
Cells must divide strictly along a plane to form an epithelial layer parallel to the basal lamina.
The axis of cell division is primarily governed by the orientation of the mitotic spindle and …
The axis of cell division is primarily governed by the orientation of the mitotic spindle and …