Fertility in female cancer survivors: pathophysiology, preservation and the role of ovarian reserve testing

K Lutchman Singh, M Davies… - Human reproduction …, 2005 - academic.oup.com
The improved long-term survival of adolescents and young women treated for cancer has
resulted in an increased focus on the effects of chemotherapy on ovarian function and its …

[HTML][HTML] In silico enhancer mining reveals SNS-032 and EHMT2 inhibitors as therapeutic candidates in high-grade serous ovarian cancer

…, L Margarit, N Das, K Lutchman-Singh… - British Journal of …, 2023 - nature.com
Background Epigenomic dysregulation has been linked to solid tumour malignancies,
including ovarian cancers. Profiling of re-programmed enhancer locations associated with …

Diffusion-weighted MRI in advanced epithelial ovarian cancer: apparent diffusion coefficient as a response marker

…, M Hall, S Freeman, JD Brenton, K Lutchman-Singh… - Radiology, 2019 - pubs.rsna.org
Background Treatment of advanced epithelial ovarian cancer results in a relapse rate of 75%.
Early markers of response would enable optimization of management and improved …

[HTML][HTML] Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade …

…, J Garcia, N Garton, N Das, K Lutchman-Singh… - Clinical …, 2023 - Springer
Background Ovarian cancer has a specific unmet clinical need, with a persistently poor 5-year
survival rate observed in women with advanced stage disease warranting continued …

[HTML][HTML] Biomarkers for site-specific response to neoadjuvant chemotherapy in epithelial ovarian cancer: relating MRI changes to tumour cell load and necrosis

…, S Freeman, E Pace, K Lutchman-Singh… - British journal of …, 2021 - nature.com
Background Diffusion-weighted magnetic resonance imaging (DW-MRI) potentially interrogates
site-specific response to neoadjuvant chemotherapy (NAC) in epithelial ovarian cancer (…

[HTML][HTML] The risk of malignancy index (RMI) in women with adnexal masses in Wales

GO Abdulrahman Jr, L McKnight, KL Singh - Taiwanese Journal of …, 2014 - Elsevier
Objective To evaluate the accuracy of the risk of malignancy index (RMI) which combines
serum CA-125 levels, ultrasound score, and menopausal state, in discriminating between …

[HTML][HTML] Dinaciclib, a bimodal agent effective against endometrial cancer

…, S Michue-Seijas, K Lutchman-Singh… - Cancers, 2021 - mdpi.com
Simple Summary Endometrial cancer (EC) is diagnosed in almost 400,000 women every year
globally and is the sixth most common cancer in women. When diagnosed early, treatment …

[HTML][HTML] Cardiac interventions in Wales: A comparison of benefits between NHS Wales specialties

…, K Smith, J Goodfellow, M Thomas, K Lutchman Singh - Plos one, 2024 - journals.plos.org
Objectives The study aimed to assess if specialised healthcare service interventions in Wales
benefit the population equitably in work commissioned by the Welsh Health Specialised …

[HTML][HTML] Dinaciclib as an effective pan-cyclin dependent kinase inhibitor in platinum resistant ovarian cancer

…, Z Coombes, SC Rees, K Lutchman-Singh… - Frontiers in …, 2022 - frontiersin.org
Background: Ovarian cancer (OC) is amongst the most lethal of common cancers in women.
Lack of specific symptoms in the early stages, OC is predominantly diagnosed late when the …

[HTML][HTML] Pelvic exenteration for the treatment of locally advanced vulvar cancer in south west wales

…, JN Vet, N Tofazzal, S Roberts, K Lutchman Singh - Cancers, 2022 - mdpi.com
Simple Summary There is no consensus on the optimal treatment strategy for locally advanced
vulvar cancer. In this paper, we aimed to highlight the outcomes from pelvic exenteration …