[HTML][HTML] Body iron metabolism and pathophysiology of iron overload

Y Kohgo, K Ikuta, T Ohtake, Y Torimoto… - International journal of …, 2008 - Springer
Iron is an essential metal for the body, while excess iron accumulation causes organ dysfunction
through the production of reactive oxygen species. There is a sophisticated balance of …

[HTML][HTML] Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis

…, N Ueno, K Moriichi, J Sasajima, K Ikuta… - Nature …, 2016 - nature.com
Previous reports have suggested that some probiotics inhibit tumorigenesis and cancer
progression. However, the molecules involved have not yet been identified. Here, we show that …

Iron overload signature in chrysotile‐induced malignant mesothelioma

…, Y Yoshikawa, H Yasui, K Ikuta… - The Journal of …, 2012 - Wiley Online Library
Exposure to asbestos is a risk for malignant mesothelioma (MM) in humans. Among the
commercially used types of asbestos (chrysotile, crocidolite, and amosite), the carcinogenicity of …

MicroRNA‐146b improves intestinal injury in mouse colitis by activating nuclear factor‐κB and improving epithelial barrier function

…, H Konishi, H Tanabe, T Ohtake, K Ikuta… - The journal of gene …, 2013 - Wiley Online Library
Background The precise role of microRNAs in inflammatory disease is not clear. The present
study investigated the effect of microRNA (miR‐146b) with respect to improving intestinal …

[HTML][HTML] Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance

Y Kohgo, K Ikuta, T Ohtake, Y Torimoto… - World journal of …, 2007 - ncbi.nlm.nih.gov
There are several cofactors which affect body iron metabolism and accelerate iron overload.
Alcohol and hepatic viral infections are the most typical examples for clarifying the role of …

Iron accumulation in alcoholic liver diseases

Y Kohgo, T Ohtake, K Ikuta, Y Suzuki… - Alcoholism: Clinical …, 2005 - Wiley Online Library
Increased hepatic iron is one of the important key factors which contribute alcohol toxicity of
liver due to the production of reactive oxygen species. In patients with alcoholic liver …

Reticulocyte hemoglobin equivalent as a potential marker for diagnosis of iron deficiency

Y Toki, K Ikuta, Y Kawahara, N Niizeki, M Kon… - International journal of …, 2017 - Springer
Abstract Evaluation of parameters relating to serum ferritin and iron is critically important in
the diagnosis of iron deficiency anemia (IDA). The recent development of automated systems …

Functional role of DMT1 in transferrin-independent iron uptake by human hepatocyte and hepatocellular carcinoma cell, HLF

M Shindo, Y Torimoto, H Saito, W Motomura, K Ikuta… - Hepatology …, 2006 - Elsevier
Non-transferrin bound iron (NTBI) in serum is cleared rapidly by hepatocytes, although the
mechanisms of NTBI uptake by hepatocytes are poorly understood. Dietary iron is transported …

Dysregulation of systemic iron metabolism in alcoholic liver diseases

Y Kohgo, T Ohtake, K Ikuta, Y Suzuki… - Journal of …, 2008 - Wiley Online Library
Alcoholic liver diseases (ALD) are frequently associated with iron overload. Until recently,
the effects of ethanol in hepatic iron uptake and intestinal iron absorption have not been …

Polyphosphate derived from Lactobacillus brevis inhibits colon cancer progression through induction of cell apoptosis

…, S Kashima, J Sasajima, K Moriichi, K Ikuta… - Anticancer …, 2016 - ar.iiarjournals.org
Although probiotics are known to have antitumor activity, few bacteria-derived antitumor
molecules have been identified. The present study explored an antitumor molecule derived from …