Different potential of C-type lectin-mediated entry between Marburg virus strains
K Matsuno, N Kishida, K Usami, M Igarashi… - Journal of …, 2010 - Am Soc Microbiol
The glycoproteins (GPs) of filoviruses are responsible for virus entry into cells. It is known
that GP interacts with cellular C-type lectins for virus attachment to cells. Since primary target …
that GP interacts with cellular C-type lectins for virus attachment to cells. Since primary target …
[HTML][HTML] A critical domain of ebolavirus envelope glycoprotein determines glycoform and infectivity
H Fujihira, K Usami, K Matsuno, H Takeuchi… - Scientific reports, 2018 - nature.com
Ebolaviruses comprises 5 species that exert varying degrees of mortality/infectivity in
humans with Reston ebolaviruses (REBOV) showing the lowest and Zaire ebolaviruses (ZEBOV) …
humans with Reston ebolaviruses (REBOV) showing the lowest and Zaire ebolaviruses (ZEBOV) …
Involvement of viral envelope GP2 in Ebola virus entry into cells expressing the macrophage galactose-type C-type lectin
K Usami, K Matsuno, M Igarashi, K Denda-Nagai… - Biochemical and …, 2011 - Elsevier
Ebola virus (EBOV) infection is initiated by the interaction of the viral surface envelope
glycoprotein (GP) with the binding sites on target cells. Differences in the mortality among different …
glycoprotein (GP) with the binding sites on target cells. Differences in the mortality among different …
Establishment of a novel monoclonal antibody against LGR5
Y Sasaki, H Kosaka, K Usami, H Toki, H Kawai… - Biochemical and …, 2010 - Elsevier
LGR5 is an orphan G-protein-coupled receptor (GPCR) that is expressed on the cell surface
membrane. LGR5 is reported to be overexpressed in colon, liver, and ovary tumor …
membrane. LGR5 is reported to be overexpressed in colon, liver, and ovary tumor …
Interleukin-4 induces specific pp-GalNAc-T expression and alterations in mucin O-glycosylation in colonic epithelial cells
A Kanoh, H Takeuchi, K Kato, M Waki, K Usami… - … et Biophysica Acta (BBA …, 2008 - Elsevier
Mucus hypersecretion occurs as a consequence of the Th2 immune response in epithelia,
yet it was not previously known whether the degree of O-glycosylation was modulated under …
yet it was not previously known whether the degree of O-glycosylation was modulated under …
A lectin recognizes differential arrangements of O-glycans on mucin repeats
K Kato, H Takeuchi, T Ohki, M Waki, K Usami… - Biochemical and …, 2008 - Elsevier
Interaction of Vicia villosa agglutinin-B4 (VVA-B4) to glycopeptides with O-linked GalNAc
residues was investigated by surface plasmon resonance. The affinity was shown to be …
residues was investigated by surface plasmon resonance. The affinity was shown to be …
Loss of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis
…, A Matsubara, Y Ohashi, M Waki, K Usami… - Glycoconjugate …, 2010 - Springer
O-glycosylation of mucin is initiated by the attachment of N-acetyl-D-galactosamine (GalNAc)
to serine or threonine residues in mucin core polypeptides by UDP-GalNAc:polypeptide N-…
to serine or threonine residues in mucin core polypeptides by UDP-GalNAc:polypeptide N-…
Novel cancer‐specific epidermal growth factor receptor antibody obtained from the serum of esophageal cancer patients with long‐term survival
S Takagi‐Maeda, S Yajima, T Suzuki, K Usami… - Cancer …, 2022 - Wiley Online Library
Although esophageal cancer has a poor prognosis after recurrence, some patients have
shown long‐term survival despite recurrence. We hypothesized that induction of either …
shown long‐term survival despite recurrence. We hypothesized that induction of either …
Properties of blocking and non-blocking monoclonal antibodies specific for human macrophage galactose-type C-type lectin (MGL/ClecSF10A/CD301)
Y Sano, K Usami, R Izawa… - The journal of …, 2007 - academic.oup.com
Monoclonal antibodies (mAbs) specific for the human macrophage galactose-type calcium-type
lectin (MGL) were established. The recombinant extracellular domain of MGL was used …
lectin (MGL) were established. The recombinant extracellular domain of MGL was used …
Current technological development of antibody therapeutics
A Yamaguchi, K Usami… - Immunology, Endocrine & …, 2011 - ingentaconnect.com
Monoclonal antibodies are now major therapeutic agents used to treat many cancers,
immunological and other diseases. Two big technological breakthroughs have enabled us to …
immunological and other diseases. Two big technological breakthroughs have enabled us to …