Anti-tumor activity of the small molecule inhibitor PRI-724 against β-catenin-activated hepatocellular carcinoma

…, K Harada, Y Mizutani, H Ouchi, K Yoshimura… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: CBP is a transcriptional coactivator in the Wnt/β-catenin pathway that is
related to cell kinetics and differentiation. This study aimed to characterize β-catenin-activated …

Diversity in cell differentiation, histology, phenotype and vasculature of mass‐forming intrahepatic cholangiocarcinomas

…, M Yamamura, Z Li, Y Sato, K Yoshimura… - …, 2021 - Wiley Online Library
Aims Mass‐forming intrahepatic cholangiocarcinomas (MF‐iCCAs), involving small bile ducts,
bile ductules or canals of Hering, remain treated as a single entity. We aimed to examine …

[HTML][HTML] Relationships between biomarkers of cartilage, bone, synovial metabolism and knee pain provide insights into the origins of pain in early knee osteoarthritis

…, H Kaneko, I Futami, K Yoshimura-Ishida… - Arthritis research & …, 2011 - Springer
Introduction We tested the hypothesis that there exist relationships between the onset of early
stage radiographically defined knee osteoarthritis (OA), pain and changes in biomarkers of …

Case of metastatic glioblastoma with primitive neuronal component to the lung

…, H Sabit, T Furuta, K Miyashita, K Yoshimura… - …, 2019 - Wiley Online Library
Glioblastoma (GBM) with primitive neuronal component (GBM‐PNC) is a rare GBM subtype
recently categorized by the World Health Organization in the revised classification system of …

A novel pathologic marker, indoleamine 2, 3-dioxygenase 1, for the cholangiopathy of immune checkpoint inhibitors-induced immune mediated hepatotoxicity as …

K Yoshimura, Y Tamano, H Nguyen Canh… - Medical Molecular …, 2023 - Springer
Immune-related adverse events (irAE) has been clarified according the usage of immune
checkpoint inhibitors(ICI). We primarily found indoleamine 2,3-dioxygenase 1(IDO-1) as a …

[HTML][HTML] Evaluation of the effect of a chicken comb extract-containing supplement on cartilage and bone metabolism in athletes

M Yoshimura, Y Aoba, T Watari… - Experimental and …, 2012 - spandidos-publications.com
In a previous study, we revealed that a commercially available product of dietary supplement
containing a chicken comb extract (CCE), which is rich in hyaluronan, not only relieves joint …

Identification of uromodulin deposition in the stroma of perinephric fibromyxoid nephrogenic adenoma by mass spectrometry

K Yoshimura, Y Ito, M Suzuki, M Horie… - Pathology …, 2023 - Wiley Online Library
Kaori Yoshimura and Yukinobu Ito contributed equally to this work. … Kaori Yoshimura
and Yukinobu Ito wrote the first draft of the manuscript, and all authors critically revised the …

SMARCB1/INI1‐deficient intrathoracic neoplasm with rhabdoid/plasmacytoid cytomorphology in a patient with plasma cell myeloma: A case report

…, C Shimaguchi, A Ito, K Yoshimura… - Diagnostic …, 2023 - Wiley Online Library
Kaori Yoshimura and Tatsuya Imi examined the clinical data of the relevant cases. Hiroko
Ikeda was responsible for the conception and design of the study and edited the final …

Anti-inflammatory and antifibrotic effects of CBP/β-catenin inhibitor for hepatocytes: small molecular inhibitor, OP-724 possibly improves liver function

H Ouchi, Y Mizutani, K Yoshimura, Y Sato… - Medical Molecular …, 2023 - Springer
Wnt/β-catenin signals are associated with several functions, including organ fibrosis. A synthetic
small molecule, OP-724 (prodrug of C-82), an inhibitor of cyclic AMP response element-…

Histiocytic sarcoma following combination chemotherapy for primary mediastinal germ cell tumor: a diagnostic dilemma

…, T Miyagi, T Nakashima, K Yoshimura… - International Cancer …, 2021 - Springer
Histiocytic sarcoma is considered an extremely rare condition. We herein report on a case of
histiocytic sarcoma following combination chemotherapy for a primary mediastinal germ cell …