Precision oncology with next generation sequencing (NGS) using tumor tissue with or without
blood has begun in Japan. Tumor molecular profiling tests are available, including the …

Purpose T-box transcription factor 21 (T-bet), which is the master regulator of effector T-cell
activation, is derived by stimulation of T-cell receptors. In this study, we focused on T-bet and …

Background/Aim: Epithelial cell adhesion molecule (EpCAM) is expressed in various types
of cancer, including breast cancer, and is correlated with metastasis, invasion, therapeutic …

Background It is important to identify biomarkers for triple-negative breast cancers (TNBCs).
Recently, pembrolizumab, an immune checkpoint inhibitor (ICI) for programmed cell death 1 …

Background/Aim: Abnormalities in the cyclin D1–CDK4/6 complex have been implicated in
breast cancer proliferation and resistance to treatment. Recently, new drugs have been …

Introduction PREDICT is a prognostication tool that calculates the potential benefit of various
postsurgical treatments on the overall survival (OS) of patients with nonmetastatic invasive …

Gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), is an
effective treatment for advanced non-small cell lung cancer (NSCLC) in patients with activating …

Introduction The optimal suction pressure during endobronchial ultrasound guided transbronchial
needle aspiration (EBUS-TBNA) remains to be determined. The aim of this study was …

Simple Summary A multigene panel test, known as comprehensive genomic profiling (CGP),
is now available in Japan for advanced cancer patients to identify suitable genotype-…

Background Primary sarcomas of the breast are rare and account for less than 1% of all
primary breast malignancies. We experienced a case of extraskeletal osteosarcoma of the …