Three syntheses of the architecturally complex, cytotoxic marine macrolide (+)-spongistatin
1 (1) are reported. Highlights of the first-generation synthesis include: use of a dithiane …

Seven hydroxyanthraquinone derivatives, 1–7, were isolated from the root of Rheum palmatum
(Polygonaceae). Two propionated anthraquinone derivatives, 8 and 9, were synthesized. …

A short, efficient, and stereocontrolled synthesis of (−)-4, an advanced ABCD subunit of the
spongistatins, has been achieved. Central to the synthetic strategy is the multicomponent …

(3β,20S,22S,25R)-22-Thiospirosol-5-en-3-ol (9) and (3β,20S,22S,25R)-22-seleno-spirosol-5-en-3-ol
(11) were prepared from diosgenin (3) via 26-iodopseudodiosgenin (6) as a key …

Vitamin D analogs 12 and 13 having a spiro ring in the side chain, various spirostanols 18–21,
26, 27, 29 and 37, and furostanols 34–36 having SCN and SeCN groups at the 26 …

1, 8-Di-O-alkylaloe-emodin derivatives (namely, methyl-, propyl-, hexyl-, dodecyl-, and
octadecyl) were synthesized from naturally occurring aloe-emodin. Further, derivatives having …

We investigated the cytotoxic activity of 2-substituted naphtho[2,3-b]furan-4,9-diones. We
have previously synthesized 33 types of 2-substituted and related compounds, and the …

A total of thirty-nine naphtho[2,3-b]furan-4,9-diones and related compounds were tested for
their cytotoxicity against three human normal oral cells (gingival fibroblast, HGF, pulp cell, …

4,9‐Dimethoxynaphtho[2,3‐b]furan 9 was obtained in 91% yield via the reductive methylation
of naphtho[2,3‐b]furan‐4,9‐dione 2. After treatment of 9 with butyllithium, the mixture was …

26-Iodopseudodiosgenin (8) and 26-iodopseudodiosgenone (9) were reacted with various
nucleophiles (KSCN, KOCN, NaCN, NaN3 and various amines) to give pseudodiosgenin …