[HTML][HTML] Dendritic actin cytoskeleton: structure, functions, and regulations

A Konietzny, J Bär, M Mikhaylova - Frontiers in cellular neuroscience, 2017 - frontiersin.org
Actin is a versatile and ubiquitous cytoskeletal protein that plays a major role in both the
establishment and the maintenance of neuronal polarity. For a long time, the most prominent …

[HTML][HTML] Dental pulp stem cell-derived secretome and its regenerative potential

JK Bar, A Lis-Nawara, PG Grelewski - International Journal of Molecular …, 2021 - mdpi.com
The therapeutic potential of the dental pulp stem (DSC) cell-derived secretome, consisting
of various biomolecules, is undergoing intense research. Despite promising in vitro and in …

[HTML][HTML] Advances in electrospun hybrid nanofibers for biomedical applications

VP Nirwan, T Kowalczyk, J Bar, M Buzgo, E Filová… - Nanomaterials, 2022 - mdpi.com
Electrospun hybrid nanofibers, based on functional agents immobilized in polymeric matrix,
possess a unique combination of collective properties. These are beneficial for a wide range …

[HTML][HTML] Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

JA Chavez, WL Holland, J Bär, K Sandhoff… - Journal of Biological …, 2005 - ASBMB
Recent studies indicate that insulin resistance and type 2 diabetes result from the accumulation
of lipids in tissues not suited for fat storage, such as skeletal muscle and the liver. To …

[HTML][HTML] Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus

A Karpova, M Mikhaylova, S Bera, J Bär, PP Reddy… - Cell, 2013 - cell.com
The activation of N-methyl-D-aspartate-receptors (NMDARs) in synapses provides plasticity
and cell survival signals, whereas NMDARs residing in the neuronal membrane outside …

Behavioural consequences of two chronic psychosocial stress paradigms: anxiety without depression

DA Slattery, N Uschold, M Magoni, J Bär… - …, 2012 - Elsevier
… Briefly, the distal 1–2 cm of the mouse tail was taped to a vertical bar, fixed on the ceiling of
a plastic box (width: 40 cm; depth: 40 cm; height: 80 cm), for 6 min. The duration of immobility, …

[HTML][HTML] Human acid ceramidase: processing, glycosylation, and lysosomal targeting

K Ferlinz, G Kopal, K Bernardo, T Linke, J Bär… - Journal of Biological …, 2001 - ASBMB
The biosynthesis of human acid ceramidase (hAC) starts with the expression of a single
precursor polypeptide of ∼53–55 kDa, which is subsequently processed to the mature, …

[HTML][HTML] Periodic F-actin structures shape the neck of dendritic spines

J Bär, O Kobler, B Van Bommel, M Mikhaylova - Scientific reports, 2016 - nature.com
Most of the excitatory synapses on principal neurons of the forebrain are located on
specialized structures called dendritic spines. Their morphology, comprising a spine head …

Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis

ARA Marques, A Di Spiezio, N Thießen, L Schmidt… - Autophagy, 2020 - Taylor & Francis
… Scale bar: 20 µm. C CTSD activity assayed with artificial fluorescent substrate in CTSD-deficient
MEFs incubated with 20 µg/mL rhCTSD for different periods (0.5–48 h). D Immunoblot of …

F‐actin patches associated with glutamatergic synapses control positioning of dendritic lysosomes

B van Bommel, A Konietzny, O Kobler, J Bär… - The EMBO …, 2019 - embopress.org
Julia Bär 1 and … Scale bar: 5 μm. Data are presented as mean ± SEM. … Red and α-LAMP1
antibody (A, scale bar: 5 μm), and α-LAMP1 and α-myosin Va/myosin VI antibody (B, Scale …