Sustained proinflammatory responses in rheumatoid arthritis, atherosclerosis, and diabetic
retinopathy, as well as in cancer, are often associated with increased angiogenesis that …

The formation of new blood vessels, or angiogenesis, is a complex process that plays important
roles in growth and development, tissue and organ regeneration, as well as numerous …

Immune checkpoint inhibitors have revolutionized medical oncology, although currently
only a subset of patients has a response to such treatment. A compelling body of evidence …

Metastatic disease is the primary cause of death in breast cancer, the most common malignancy
in Western women. Loss of E-cadherin is associated with tumor metastasis, as well as …

The antimetastatic ruthenium(II) compounds [Ru(η 6 -p-cymene)Cl 2 (PTA)] (PTA = 1,3,5-triaza-7-phosphaadamantane)
(RAPTA-C) and [Ru(η 6 -toluene)Cl 2 (PTA)] (RAPTA-T), as well …

Crucial to designing angiostatic and vascular targeting agents is the identification of target
molecules. Because angiogenesis is not limited to pathologic conditions, careful evaluation of …

The concept of antiangiogenic therapy in cancer treatment has led to the approval of different
agents, most of them targeting the well known vascular endothelial growth factor pathway. …

Here, we present a protocol for the isolation of endothelial cells (ECs) from tissues. ECs make
up a minor population of cells in a tissue, but play a major role in tissue homeostasis, as …

Purpose: To investigate the angiogenic changes in primary tumor tissue of renal cell carcinoma
(RCC) patients treated with VEGF-targeted therapy. Experimental Design: Phase II trials …

Anti-angiogenic cancer therapies possess immune-stimulatory properties by counteracting
pro-angiogenic molecular mechanisms. We report that tumor endothelial cells ubiquitously …