[HTML][HTML] Continuous treatment with all-transretinoic acid causes a progressive reduction in plasma drug concentrations: implications for relapse and retinoid “ …

J Muindi, SR Frankel, WH Miller Jr, A Jakubowski… - Blood, 1992 - Elsevier
Although all-transretinoic acid (RA) induces complete remission in a high proportion of
patients with acute promyelo-cytic leukemia (APL), all groups have described clinical relapses …

Clinical Pharmacology of Oral All-trans Retinoic Acid in Patients with Acute Promyelocytic Leukemia

JRF Muindi, SR Frankel, C Huselton, F DeGrazia… - Cancer research, 1992 - AACR
All-trans retinoic acid (RA) induces leukemic cell differentiation and complete remission in a
high proportion of patients with acute promyelocytic leukemia (APL). However, remissions …

Anti-tumor activity of calcitriol: pre-clinical and clinical studies

…, RJ Bernardi, S Ahmed, J Muindi… - The Journal of steroid …, 2004 - Elsevier
1,25-Dihydroxycholecalciferol (calcitriol) is recognized widely for its effects on bone and
mineral metabolism. Epidemiological data suggest that low Vitamin D levels may play a role in …

A Phase I trial of calcitriol (1, 25-dihydroxycholecalciferol) in patients with advanced malignancy

DC Smith, CS Johnson, CC Freeman, J Muindi… - Clinical cancer …, 1999 - AACR
Vitamin D is a steroid hormone best known for its activity in regulating calcium and bone
metabolism. Epidemiological evidence suggests that vitamin D may play a role in inhibiting the …

Hydroxyl radical production and DNA damage induced by anthracycline‐iron complex

JRF Muindi, BK Sinha, L Gianni, CE Myers - FEBS letters, 1984 - Wiley Online Library
Adriamycin‐Fe 3+ complex catalyzes the formation of hydroxyl radical from hydrogen
peroxide but the DNA‐adriamycin‐iron ternary complex is much more effective. 11‐…

Feasibility of retinoids for the treatment of emphysema study

…, PJ Friedman, JG Goldin, TA Louis, JT Mao, JR Muindi… - Chest, 2006 - Elsevier
Background Retinoids promote alveolar septation in the developing lung and stimulate alveolar
repair in some animal models of emphysema. Methods One hundred forty-eight subjects …

Phase II trial of high‐dose, intermittent calcitriol (1, 25 dihydroxyvitamin D3) and dexamethasone in androgen‐independent prostate cancer

DL Trump, DM Potter, J Muindi, A Brufsky… - Cancer, 2006 - Wiley Online Library
BACKGROUND Data suggest that vitamin D plays a role in the treatment and prevention of
prostate cancer. The combination of high‐dose, intermittent calcitriol (1,25 dihydroxyvitamin …

Pharmacokinetics of high‐dose oral calcitriol: results from a phase 1 trial of calcitriol and paclitaxel

JR Muindi, Y Peng, DM Potter… - Clinical …, 2002 - Wiley Online Library
Objectives The data reported are from a trial designed to determine, in patients with
advanced cancer, the maximum tolerated dose and pharmacokinetics of calcitriol when …

CYP24A1 inhibition enhances the antitumor activity of calcitriol

JR Muindi, WD Yu, Y Ma, KL Engler, RX Kong… - …, 2010 - academic.oup.com
High systemic exposures to calcitriol are necessary for optimal antitumor effects. Human
prostate cancer PC3 cells are insensitive to calcitriol treatment. Therefore, we investigated …

Epigenetic Regulation of Vitamin D 24-Hydroxylase/CYP24A1 in Human Prostate Cancer

W Luo, AR Karpf, KK Deeb, JR Muindi, CD Morrison… - Cancer research, 2010 - AACR
Calcitriol, a regulator of calcium homeostasis with antitumor properties, is degraded by the
product of the CYP24A1 gene, which is downregulated in human prostate cancer by unknown …