Vitamin D3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling

HG Pálmer, JM González-Sancho, J Espada… - The Journal of cell …, 2001 - rupress.org
… HG Pálmer and JM González-Sancho contributed equally to … HG Pálmer and JM
González-Sancho were recipients of … HG Pálmer and JM González-Sancho contributed equally to …

The Wnt antagonist DICKKOPF-1 gene is induced by 1α,25-dihydroxyvitamin D 3 associated to the differentiation of human colon cancer …

…, C Gamallo, F Bonilla, JM González-Sancho… - …, 2007 - academic.oup.com
The Wnt–β-catenin pathway is aberrantly activated in most colon cancers. DICKKOPF-1 (
DKK-1 ) gene encodes an extracellular Wnt inhibitor that blocks the formation of signalling …

Vitamin D and Wnt/β-catenin pathway in colon cancer: role and regulation of DICKKOPF genes

…, O Aguilera, F Pereira, JM González-Sancho… - Anticancer …, 2008 - ar.iiarjournals.org
Colorectal cancer is a major health problem worldwide. Aberrant activation of the Wingless-type
mouse mammary tumour virus integration site family (Wnt)/β-catenin signalling pathway …

Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway

C Caelles, JM González-Sancho… - Genes & …, 1997 - genesdev.cshlp.org
The activity of c-Jun, the major component of the transcription factor AP-1, is potentiated by
amino-terminal phosphorylation on serines 63 and 73 (Ser-63/73). This phosphorylation is …

[HTML][HTML] Vitamin D is a multilevel repressor of Wnt/β-catenin signaling in cancer cells

MJ Larriba, JM González-Sancho, A Barbáchano… - Cancers, 2013 - mdpi.com
The Wnt/β-catenin signaling pathway is abnormally activated in most colorectal cancers and
in a proportion of other neoplasias. This activation initiates or contributes to carcinogenesis …

Vitamin D regulates the phenotype of human breast cancer cells

N Pendás-Franco, JM González-Sancho, Y Suárez… - Differentiation, 2007 - Elsevier
1α,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), the most active vitamin D metabolite, regulates
proliferation, survival, and differentiation in many cell types. 1,25(OH) 2 D 3 and several …

Wnt proteins induce dishevelled phosphorylation via an LRP5/6-independent mechanism, irrespective of their ability to stabilize β-catenin

JM González-Sancho, KR Brennan… - … and cellular biology, 2004 - Taylor & Francis
Wnt glycoproteins play essential roles in the development of metazoan organisms. Many
Wnt proteins, such as Wnt1, activate the well-conserved canonical Wnt signaling pathway, …

Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer

JM Silva, G Domínguez, JM González-Sancho… - Oncogene, 2002 - nature.com
The relation between thyroid status and diseases and cancer is unclear. No detailed analysis
of thyroid hormone receptor (TR) expression in human breast cancer has been reported. …

Glucocorticoids antagonize AP-1 by inhibiting the activation/phosphorylation of JNK without affecting its subcellular distribution

…, JM González-Sancho, C Caelles, M Lafarga… - The Journal of cell …, 2000 - rupress.org
The immunosuppressive and antiinflammatory actions of glucocorticoid hormones are
mediated by their transrepression of activating protein-1 (AP-1) and nuclear factor-kappa B (NFκB…

[HTML][HTML] The inhibition of Wnt/β-catenin signalling by 1α, 25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells

…, AG de Herreros, JM González-Sancho… - Endocrine-related …, 2007 - erc.bioscientifica.com
The Wnt/β-catenin signalling pathway is activated in 90% of human colon cancers by
nuclear accumulation of β-catenin protein due to its own mutation or to that of adenomatous …