User profiles for JOHN J. L. JACOBS

Jacob John

- Verified email at cmcsph.org - Cited by 2832

John JL Jacobs

- Verified email at ortec.com - Cited by 1483

[HTML][HTML] Local therapy of cancer with free IL-2

W Den Otter, JJL Jacobs, JJ Battermann… - Cancer Immunology …, 2008 - Springer
This is a position paper about the therapeutic effects of locally applied free IL-2 in the treatment
of cancer. Local therapy: IL-2 therapy of cancer was originally introduced as a systemic …

The surveillance for enteric fever in Asia project (SEAP), severe typhoid fever surveillance in Africa (SETA), surveillance of enteric fever in India (SEFI), and strategic …

…, M Terferi, S Islam, O Lunguya, J Jacobs… - Clinical Infectious …, 2020 - academic.oup.com
Building on previous multicountry surveillance studies of typhoid and others salmonelloses
such as the Diseases of the Most Impoverished program and the Typhoid Surveillance in …

Persistent SARS-2 infections contribute to long COVID-19

JJL Jacobs - Medical hypotheses, 2021 - Elsevier
COVID-19 is a serious disease that has infected more than 40 million people. Beside
significant mortality, the SARS-CoV-2 infection causes considerable and sustained morbidity, …

Stratum corneum cytokines and skin irritation response to sodium lauryl sulfate

…, MM Verberk, CET Withagen, JJL Jacobs… - Contact …, 2006 - Wiley Online Library
Little is known about cytokines involved in chronic irritant contact dermatitis. Individual cytokine
profiles might explain at least part of the differences in the individual response to irritation…

In situ crosslinked biodegradable hydrogels loaded with IL-2 are effective tools for local IL-2 therapy

GW Bos, JJL Jacobs, JW Koten, S Van Tomme… - European journal of …, 2004 - Elsevier
We investigated the therapeutic efficacy of recombinant human interleukin-2 (rhIL-2)-loaded,
in situ gelling, physically crosslinked dextran hydrogels, locally applied to SL2 lymphoma in …

In vitro and in vivo protein delivery from in situ forming poly (ethylene glycol)–poly (lactide) hydrogels

…, JJL Jacobs, W Den Otter, WE Hennink, J Feijen - Journal of controlled …, 2007 - Elsevier
Previous studies have shown that stereocomplexed hydrogels are rapidly formed in situ by
mixing aqueous solutions of eight-arm poly(ethylene glycol)-poly(L-lactide) and poly(…

[HTML][HTML] Toward rapid, widely available autologous CAR-T cell therapy–artificial intelligence and automation enabling the smart manufacturing hospital

…, I Papantoniou, M Hudecek, JJL Jacobs… - Frontiers in …, 2022 - frontiersin.org
CAR-T cell therapy is a promising treatment for acute leukemia and lymphoma. CAR-T cell
therapies take a pioneering role in autologous gene therapy with three EMA-approved …

[HTML][HTML] Real-time imputation of missing predictor values improved the application of prediction models in daily practice

…, J Hoogland, ML Bots, M Brandjes, JJL Jacobs… - Journal of clinical …, 2021 - Elsevier
Objectives In clinical practice, many prediction models cannot be used when predictor values
are missing. We, therefore, propose and evaluate methods for real-time imputation. Study …

Inefficacy of therapeutic cancer vaccines and proposed improvements. Casus of prostate cancer

JJL Jacobs, C Snackey, AA Geldof… - Anticancer …, 2014 - ar.iiarjournals.org
Prophylactic vaccination is arguably the most effective medical preventative method. After
local inoculation, vaccines induce antigen-specific systemic immunity, protecting the whole …

Effective treatment of transmissible venereal tumors in dogs with vincristine and IL2

W DEN OTTER, M Hack, JJL Jacobs, JFV Tan… - Anticancer …, 2015 - ar.iiarjournals.org
Aim: To improve treatment of inoperable transmissible venereal tumors (TVTs) in dogs.
Recently, we showed that TVT is sensitive to intratumoral treatment with interleukin-2 (IL2). In …