Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-γ
JS Nair, CJ DaFonseca, A Tjernberg… - Proceedings of the …, 2002 - National Acad Sciences
In response to IFN-γ, the latent cytoplasmic protein signal transducers and activators of
transcription 1 (Stat1) becomes phosphorylated on Y701, dimerizes, and accumulates in the …
transcription 1 (Stat1) becomes phosphorylated on Y701, dimerizes, and accumulates in the …
Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780
JS Nair, AL Ho, AN Tse, J Coward… - Molecular biology of …, 2009 - Am Soc Cell Biol
The phenotypic change characteristic of Aurora B inhibition is the induction of polyploidy.
Utilizing specific siRNA duplexes and a selective small molecule inhibitor (AZD1152) to inhibit …
Utilizing specific siRNA duplexes and a selective small molecule inhibitor (AZD1152) to inhibit …
Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets
ML Miller, EJ Molinelli, JS Nair, T Sheikh, R Samy… - Science …, 2013 - science.org
Dedifferentiated liposarcoma (DDLS) is a rare but aggressive cancer with high recurrence
and low response rates to targeted therapies. Increasing treatment efficacy may require …
and low response rates to targeted therapies. Increasing treatment efficacy may require …
[HTML][HTML] Impact of combined mTOR and MEK inhibition in uveal melanoma is driven by tumor genotype
…, E Musi, G Ambrosini, JS Nair, S Deraje Vasudeva… - PloS one, 2012 - journals.plos.org
Uveal melanomas possess activation of the mitogen-activated protein kinase (MAPK) and
phosphoinositide 3-kinase (PI3K)/AKT/mammalian Target of Rapamycin (mTOR) pathways. …
phosphoinositide 3-kinase (PI3K)/AKT/mammalian Target of Rapamycin (mTOR) pathways. …
The Checkpoint Kinase Inhibitor AZD7762 Potentiates Chemotherapy-Induced Apoptosis of p53-Mutated Multiple Myeloma Cells
HJ Landau, SC McNeely, JS Nair, RL Comenzo… - Molecular cancer …, 2012 - AACR
DNA cross-linking agents are frequently used in the treatment of multiple myeloma–generating
lesions, which activate checkpoint kinase 1 (Chk1), a critical transducer of the DNA …
lesions, which activate checkpoint kinase 1 (Chk1), a critical transducer of the DNA …
Selinexor (KPT-330) induces tumor suppression through nuclear sequestration of IκB and downregulation of survivin
JS Nair, E Musi, GK Schwartz - Clinical Cancer Research, 2017 - AACR
Purpose: Selinexor, a small molecule that inhibits nuclear export protein XPO1, has
demonstrated efficacy in solid tumors and hematologic malignancies with the evidence of clinical …
demonstrated efficacy in solid tumors and hematologic malignancies with the evidence of clinical …
The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependent
JS Nair, AL Ho, GK Schwartz - Cell cycle, 2012 - Taylor & Francis
Aurora kinases are mitotic serine/threonine protein kinases and are attractive novel targets
for anticancer therapy. Many small-molecule inhibitors of Aurora kinases are currently …
for anticancer therapy. Many small-molecule inhibitors of Aurora kinases are currently …
Energy efficient lattice and surface chemical regeneration of graphite from failed Li-ion batteries and its use as ultra-long cycling Na-ion battery anodes
SS Jayasree, B Gangaja, DS Baji, AV Nair… - Resources …, 2023 - Elsevier
Graphite being the most used anode in commercial lithium ion batteries (LIBs), haven't
receive much attraction in recycling research. Also, graphite has limited attraction for Na-ion …
receive much attraction in recycling research. Also, graphite has limited attraction for Na-ion …
Ultrathin TiO2 Coating on LiCoO2 for Improved Electrochemical Performance as Li–Ion Battery Cathode
SS Jayasree, S Nair, D Santhanagopalan - ChemistrySelect, 2018 - Wiley Online Library
Surface modification of LiCoO 2 (LCO) gained much attention as it could play a prominent
role in improving electrochemical performance and structural stability. Herein, we report an …
role in improving electrochemical performance and structural stability. Herein, we report an …
[HTML][HTML] MLN-8237: A dual inhibitor of aurora A and B in soft tissue sarcomas
JS Nair, GK Schwartz - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aurora kinases have become an attractive target in cancer therapy due to their deregulated
expression in human tumors. Liposarcoma, a type of soft tissue sarcoma in adults, account …
expression in human tumors. Liposarcoma, a type of soft tissue sarcoma in adults, account …