User profiles for JASON M. SHOHET
Jason ShohetUniversity of Massachusetts Medical school Verified email at umassmed.edu Cited by 4193 |
Neuroblastoma: molecular pathogenesis and therapy
CU Louis, JM Shohet - Annual review of medicine, 2015 - annualreviews.org
Neuroblastoma is a developmental tumor of young children arising from the embryonic
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death from …
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death from …
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma
…, L Hunt, A Pession, JM Shohet - Proceedings of the …, 2005 - National Acad Sciences
The MYCN oncogene is the major negative prognostic marker in neuroblastoma with important
roles in both the pathogenesis and clinical behavior of this aggressive malignancy. MYC …
roles in both the pathogenesis and clinical behavior of this aggressive malignancy. MYC …
A gold nanoparticle platform for the delivery of functional microRNAs into cancer cells
Lack of affordable technologies for delivering microRNAs and siRNAs into cells on a large
scale has hindered our efforts to rapidly parse through hundreds of dysregulated genes/…
scale has hindered our efforts to rapidly parse through hundreds of dysregulated genes/…
[HTML][HTML] PRMT5 activates AKT via methylation to promote tumor metastasis
…, JP Cavaretta, G Wang, L Zhang, JM Shohet… - Nature …, 2022 - nature.com
Protein arginine methyltransferase 5 (PRMT5) is the primary methyltransferase generating
symmetric-dimethyl-arginine marks on histone and non-histone proteins. PRMT5 …
symmetric-dimethyl-arginine marks on histone and non-histone proteins. PRMT5 …
MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced apoptotic cell death
…, Z Chen, L Zhang, A Slack, S Berg, JM Shohet - Molecular cancer …, 2006 - AACR
… Eveline Barbieri, Parth Mehta, Zaowen Chen, Linna Zhang, Andrew Slack, Stacey Berg,
Jason M. Shohet; MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced …
Jason M. Shohet; MDM2 inhibition sensitizes neuroblastoma to chemotherapy-induced …
Neuroblastoma pathogenesis: deregulation of embryonic neural crest development
Neuroblastoma (NB) is an aggressive pediatric cancer that originates from neural crest tissues
of the sympathetic nervous system. NB is highly heterogeneous both from a clinical and a …
of the sympathetic nervous system. NB is highly heterogeneous both from a clinical and a …
WDR5 supports an N-Myc transcriptional complex that drives a protumorigenic gene expression signature in neuroblastoma
…, B Atmadibrata, M Wong, T Trahair, Q Zhao, JM Shohet… - Cancer research, 2015 - AACR
MYCN gene amplification in neuroblastoma drives a gene expression program that correlates
strongly with aggressive disease. Mechanistically, trimethylation of histone H3 lysine 4 (…
strongly with aggressive disease. Mechanistically, trimethylation of histone H3 lysine 4 (…
G-CSF promotes neuroblastoma tumorigenicity and metastasis via STAT3-dependent cancer stem cell activation
Increasing evidence suggests that inflammatory cytokines play a critical role in tumor initiation
and progression. A cancer stem cell (CSC)-like subpopulation in neuroblastoma is known …
and progression. A cancer stem cell (CSC)-like subpopulation in neuroblastoma is known …
The role of histone demethylase KDM4B in Myc signaling in neuroblastoma
…, C Qu, AC Nathwani, JM Shohet… - Journal of the …, 2015 - academic.oup.com
Background: Epigenetic alterations, such as histone methylation, modulate Myc signaling, a
pathway central to oncogenesis. We investigated the role of the histone demethylase …
pathway central to oncogenesis. We investigated the role of the histone demethylase …
Anti-gene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis
We developed an anti-gene peptide nucleic acid (PNA) for selective inhibition of MYCN
transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA …
transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA …