Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology
JS Jepsen, MD Sørensen, J Wengel - Oligonucleotides, 2004 - liebertpub.com
Locked nucleic acid (LNA) is a class of nucleic acid analogs possessing very high affinity
and excellent specificity toward complementary DNA and RNA, and LNA oligonucleotides …
and excellent specificity toward complementary DNA and RNA, and LNA oligonucleotides …
Recent developments in the surgical management of benign prostatic hyperplasia
JV Jepsen, RC Bruskewitz - Urology, 1998 - Elsevier
A new era in the surgical management of benign prostatic hyperplasia (BPH) has emerged
in the past decade. A variety of less invasive treatment modalities have been introduced and …
in the past decade. A variety of less invasive treatment modalities have been introduced and …
LNA-antisense rivals siRNA for gene silencing.
JS Jepsen, J Wengel - Current opinion in drug discovery & …, 2004 - europepmc.org
Locked nucleic acid (LNA) is a class of nucleic acid analogs possessing unprecedented
binding affinity toward complementary DNA and RNA while obeying the Watson-Crick base-…
binding affinity toward complementary DNA and RNA while obeying the Watson-Crick base-…
Modulation of CpG oligodeoxynucleotide-mediated immune stimulation by locked nucleic acid (LNA)
J Vollmer, JS Jepsen, E Uhlmann, C Schetter… - …, 2004 - liebertpub.com
Locked nucleic acid (LNA) is an RNA derivative that when introduced into oligodeoxynucleotides
(ODN), mediates high efficacy and stability. CpG ODNs are potent immune stimulators …
(ODN), mediates high efficacy and stability. CpG ODNs are potent immune stimulators …
Long-term experience with pentosanpolysulfate in interstitial cystitis
JV Jepsen, M Sall, PR Rhodes, D Schmidt, E Messing… - Urology, 1998 - Elsevier
Objectives. An oral preparation of pentosanpolysulfate sodium (PPS) was recently approved
by the Food and Drug Administration for interstitial cystitis (IC). Previously published articles …
by the Food and Drug Administration for interstitial cystitis (IC). Previously published articles …
Comprehensive patient evaluation for benign prostatic hyperplasia
JV Jepsen, RC Bruskewitz - Urology, 1998 - Elsevier
It is time to consider new approaches to benign prostatic hyperplasia (BPH). Previously,
obstruction, prostatism, and hyperplasia of the prostate were considered to be almost …
obstruction, prostatism, and hyperplasia of the prostate were considered to be almost …
Design and validation of a cross‐specialty simulation‐based training course in basic robotic surgical skills
SI Scott, T Dalsgaard, JV Jepsen… - … Journal of Medical …, 2020 - Wiley Online Library
Background The aim of this study was to design and validate a cross‐specialty basic robotic
surgical skills training program on the RobotiX Mentor virtual reality simulator. Methods A …
surgical skills training program on the RobotiX Mentor virtual reality simulator. Methods A …
Validation of a novel simulation-based test in robot-assisted radical prostatectomy
Purpose: To investigate validity evidence for a simulator-based test in robot-assisted radical
prostatectomy (RARP). Materials and Methods: The test consisted of three modules on the …
prostatectomy (RARP). Materials and Methods: The test consisted of three modules on the …
Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3′-C-ethynyluridine (EUrd) and 3′-C-ethynylcytidine (ECyd)
PJ Hrdlicka, JS Jepsen, C Nielsen, J Wengel - Bioorganic & medicinal …, 2005 - Elsevier
A series of nucleobase-modified analogs of the anticancer compounds 3′-C-ethynyluridine
(EUrd) and 3′-C-ethynylcytidine (ECyd) were designed to overcome the strict substrate …
(EUrd) and 3′-C-ethynylcytidine (ECyd) were designed to overcome the strict substrate …
Downregulation of p21(WAF1/CIP1) and Estrogen Receptor α in MCF-7 Cells by Antisense Oligonucleotides Containing Locked Nucleic Acid (LNA)
JS Jepsen, HM Pfundheller, AE Lykkesfeldt - Oligonucleotides, 2004 - liebertpub.com
Locked nucleic acid (LNA) is a nucleic acid analog with very high affinity to complementary
RNA and a promising compound in the field of antisense research. The intracellular …
RNA and a promising compound in the field of antisense research. The intracellular …