Breast cancer is the leading cause of death among solid tumours in women, and its
incidence is increasing in the West. Adjuvant chemotherapy and hormonal treatment improve …

Endometrial" hyperplasia," as currently diagnosed, includes the changes caused by an
abnormal hormonal state and those caused by a separate category of monoclonal premalignant …

PURPOSE: We assessed the reproducibility and prognostic variability of grade and lamina
propria invasion in stages Ta, T1 urothelial carcinoma of the bladder. MATERIALS AND …

The microscopic phenotype of cervical intraepithelial neoplasia (CIN) reflects a fine balance
between factors that promote or reduce CIN development. A shortcoming of the current …

Background: PTEN tumor suppressor gene mutations are the most frequent genetic lesions
in endometrial adenocarcinomas of the endometrioid subtype. Testing the hypothesis that …

The Multicenter Morphometric Mammary Carcinoma Project is a prospective study on the
reproducibility and prognostic value of routine quantitative assessments, especially the mitotic …

Management of endometrial precancers is compromised by longstanding debate over the
natural history of endometrial hyperplasias and inconsistencies in their diagnosis. The recent …

Growth factors may play an important role in tumour growth and angiogenesis by their influence
on tumour cell proliferation or their effect on neovascularization. The aim of the present …

Discovery of somatically mutated cells in human tissues has been less frequent than would
be predicted by in vitro mutational rates. We analyzed the PTEN tumor suppressor gene as …

In 271 breast cancer patients with adequate follow‐up for at least 5.5 and maximally 12
years, the value of morphometry to classic prognosticators of breast cancer (tumor size and …