[HTML][HTML] MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside

…, M Ghidini, M Salati, MB Mirchev, N Valeri, JC Hahne - Targeted …, 2020 - Springer
Non-coding RNAs represent a significant proportion of the human genome. After having been
considered as ‘junk’ for a long time, non-coding RNAs are now well established as playing …

[HTML][HTML] Microsatellite instability in gastric cancer: molecular bases, clinical perspectives, and new treatment approaches

M Ratti, A Lampis, JC Hahne, R Passalacqua… - Cellular and Molecular …, 2018 - Springer
Gastric cancer is one of the most aggressive malignancies, with limited treatment options in
both locally advanced and metastatic setting, resulting in poor prognosis. Based on genomic …

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

…, Z Eltahir, EC Smyth, R Begum, PA Clarke, JC Hahne… - Science, 2018 - science.org
Patient-derived organoids (PDOs) have recently emerged as robust preclinical models;
however, their potential to predict clinical outcomes in patients has remained unclear. We report …

The potential of proteasome inhibitors in cancer therapy

J Sterz, I Metzler, JC Hahne, B Lamottke… - Expert opinion on …, 2008 - Taylor & Francis
Background: The ubiquitin-proteasome system has become a promising novel molecular
target in cancer due to its critical role in cellular protein degradation, its interaction with cell …

[HTML][HTML] Effect of pathologic tumor response and nodal status on survival in the medical research council adjuvant gastric infusional chemotherapy trial

…, AFC Okines, A Lampis, JC Hahne… - Journal of Clinical …, 2016 - ncbi.nlm.nih.gov
Purpose The Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC)
trial established perioperative epirubicin, cisplatin, and fluorouracil chemotherapy as a …

Longitudinal liquid biopsy and mathematical modeling of clonal evolution forecast time to treatment failure in the PROSPECT-C phase II colorectal cancer clinical trial

…, A Bryant, T Jones, P Proszek, M Fassan, JC Hahne… - Cancer discovery, 2018 - AACR
Sequential profiling of plasma cell-free DNA (cfDNA) holds immense promise for early detection
of patient progression. However, how to exploit the predictive power of cfDNA as a liquid …

The Ets-1 transcription factor is involved in the development and invasion of malignant melanoma

T Rothhammer, JC Hahne, A Florin, I Poser… - Cellular and Molecular …, 2004 - Springer
The Ets-1 transcription factor plays a role in tumor vascularization and invasion by regulating
expression of matrix-degrading proteases in endothelial cells and fibroblasts in the tumor …

[HTML][HTML] MIR21 drives resistance to heat shock protein 90 inhibition in cholangiocarcinoma

…, MA Bali, C Nepal, K Khan, M Stubbs, JC Hahne… - Gastroenterology, 2018 - Elsevier
Background & Aims Cholangiocarcinomas (CCA) are resistant to chemotherapy, so new
therapeutic agents are needed. We performed a screen to identify small-molecule compounds …

Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers

…, L Boulter, R Guest, L Quagliata, JC Hahne… - Gut, 2017 - gut.bmj.com
Objective Transcribed-ultraconserved regions (T-UCR) are long non-coding RNAs which
are conserved across species and are involved in carcinogenesis. We studied T-UCRs …

[HTML][HTML] Use of antibiotics and risk of cancer: a systematic review and meta-analysis of observational studies

…, S Khakoo, E Oggionni, C Abeni, JC Hahne… - Cancers, 2019 - mdpi.com
The association between antibiotic use and risk of cancer development is unclear, and clinical
trials are lacking. We performed a systematic review and meta-analysis of observational …