To evaluate whether mutations in the human multidrug resistance (MDR)-1 gene correlate
with placental P-glycoprotein (PGP) expression, we sequenced the MDR-1 cDNA and …

Objective: Our objective was to quantitate the contribution of the genetic polymorphisms of the
genes for 2 human organic anion transporters—organic anion transporting polypeptide C (…

Objective To investigate pharmacokinetic and pharmacodynamic factors associated with
population differences in warfarin doses needed to achieve anticoagulation, in particular the …

The aim of the present study was to assess the contribution of polymorphisms in the breast
cancer resistance protein/ATP-binding cassette transporter G2 (BCRP/ABCG2) gene to the …

Objective Our objective was to quantitate the contribution of the genetic polymorphism of the
human MDR1 gene to the bioavailability and interaction profiles of digoxin, a substrate of P‐…

Purpose. The aim of the current study was to identify the effect of single nucleotide
polymorphisms (SNPs) in breast cancer resistance protein (BCRP/ABCG2) on its localization, …

Organic cation transporters (OCTs) are responsible for the hepatic and renal transport of
metformin. In this study we analyzed variants of OCT1 and OCT2 genes in 33 patients (24 …

Genotypings of two mutations (* 2 and* 3) in CYP2C19 and the amino acid variants (Arg 144/Cys,
Tyr 358/Cys, Ile 359/Leu, and Gly 417/Asp) in CYP2C9 were carried out in 140 …

Background. Tacrolimus is a substrate of P-glycoprotein (PGP) encoded by the multidrug
resistant (MDR) 1 gene (ABCB1). PGP, a multidrug efflux pump, restricts the distribution of …

Recent pharmacogenomic/pharmacogenetic studies have disclosed important roles of drug
transporters in the pharmacokinetic/pharmacodynamic (PK/PD) profiles of some clinically …