Since the initial clinical approval in the late 1990s and remarkable anticancer effects for certain
types of cancer, molecular targeted therapy utilizing small molecule agents or therapeutic …

Inducible cyclooxygenase (COX-2) has been implicated in the processes of inflammation
and carcinogenesis. Thus, the potential COX-2 inhibitors have been considered as anti-…

Brazilin (7,11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10 (6H)-tetrol) isolated from
Caesalpinia sappan has been known as a natural red pigment. Many studies suggest that …

Non-small cell lung cancer (NSCLC), which represents 80–85% of lung cancer cases, is
one of the leading causes of human death worldwide. The majority of patients undergo an …

In order to search an effective extraction of resveratrol from grapes, superior to a conventional
solvent extraction, an ultrasonication-assisted method was explored. When the new …

Caffeic acid phenethyl ester (CAPE) derived from honeybee propolis has been used as a folk
medicine. Recent study also revealed that CAPE has several biological activities including …

Prostaglandins and nitric oxide produced by inducible cyclooygenase (COX-2) and nitric
oxide synthase (iNOS), respectively, have been implicated as important mediators in the …

Honokiol is a naturally occurring neolignan abundant in Magnoliae Cortex and has showed
anti-proliferative and pro-apoptotic effects in a wide range of human cancer cells. However, …

Abnormal activation of the canonical Wnt/β-catenin pathway and up-regulation of the β-catenin/T-cell
factor (TCF) response to transcriptional signaling play a critical role early in …

Dibenzocyclooctadiene lignans isolated from Schisandra chinensis showed antiproliferative
effects in various human cancer cells. The methoxy groups at C-3, C-4, C-3′, and C-4′, …