[HTML][HTML] Morphological adjustment of senescent cells by modulating caveolin-1 status

…, YS Oh, JH Park, JW Lee, HP Kim, KT Kim… - Journal of Biological …, 2004 - ASBMB
Morphological change is one of the cardinal features of the senescent phenotype; for
example, senescent human diploid cells have a flat large shape. However, the mechanisms …

[HTML][HTML] Targeted sequencing of cancer-related genes in colorectal cancer using next-generation sequencing

…, KJ Park, JG Park, GH Kang, JS Seo, JI Kim, TY Kim - PloS one, 2013 - journals.plos.org
Recent advance in sequencing technology has enabled comprehensive profiling of genetic
alterations in cancer. We have established a targeted sequencing platform using next-…

KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: Implication for combinatorial approach

YK Yoon, HP Kim, SW Han, DY Oh… - … in cooperation with …, 2010 - Wiley Online Library
KRAS is frequently mutated in nonsmall cell lung cancer (NSCLC), resulting in the activation
of the MAPK/ERK kinase (MEK)/ERK pathway. High‐throughput mutation profile has shown …

RAD51C-deficient cancer cells are highly sensitive to the PARP inhibitor olaparib

…, HP Kim, KH Lee, SW Han, DY Oh, TY Kim… - Molecular cancer …, 2013 - AACR
A PARP inhibitor is a rationally designed targeted therapy for cancers with impaired DNA
repair abilities. RAD51C is a paralog of RAD51 that has an important role in the DNA damage …

Trastuzumab inhibits the growth of human gastric cancer cell lines with HER2 amplification synergistically with cisplatin

SY Kim, HP Kim, YJ Kim, DY Oh… - International …, 2008 - spandidos-publications.com
HER2 has been found to be amplified in 10-20% of gastric cancers, and is correlated with
poor outcome. The aims of this study were to recognize HER2 amplification in gastric cancer …

RNA editing in RHOQ promotes invasion potential in colorectal cancer

…, HP Kim, JY Shin, EG Jeong, WC Lee, KY Kim… - Journal of Experimental …, 2014 - rupress.org
RNA editing can increase RNA sequence variation without altering the DNA sequence. By
comparing whole-genome and transcriptome sequence data of a rectal cancer, we found …

The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines

JW Kim, HP Kim, SA Im, S Kang, HS Hur, YK Yoon… - Cancer letters, 2008 - Elsevier
HER2 overexpression is observed in 5–25% of gastric cancers. Lapatinib is a dual inhibitor
of the epidermal growth factor receptor and HER2 tyrosine kinase. We examined the …

OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells

MJ Kim, HJ Nam, HP Kim, SW Han, SA Im, TY Kim… - Cancer letters, 2013 - Elsevier
We investigated the mechanisms of action and antitumor effects of OPB-31121, a novel STAT3
inhibitor, in gastric cancer cells. OPB-31121 downregulated JAK2 and gp130 expression …

[HTML][HTML] Lapatinib, a dual EGFR and HER2 tyrosine kinase inhibitor, downregulates thymidylate synthase by inhibiting the nuclear translocation of EGFR and HER2

HP Kim, YK Yoon, JW Kim, SW Han, HS Hur, J Park… - PloS one, 2009 - journals.plos.org
Background Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) has been
shown to exert a synergistic antitumor effect when combined with fluoropyrimidine. This …

[HTML][HTML] Personalised circulating tumour DNA assay with large-scale mutation coverage for sensitive minimal residual disease detection in colorectal cancer

…, SH Cho, J Ahn, JK Kang, SY Kim, HP Kim… - British journal of …, 2023 - nature.com
Background Postoperative minimal residual disease (MRD) detection using circulating-tumour
DNA (ctDNA) requires a highly sensitive analysis platform. We have developed a tumour-…