Comprehensive molecular profiling broadens treatment options for breast cancer patients -
Kawaji - 2021 - … Hitomi Kawaji and Makoto Kubo have contributed equally to this work. …

Purpose T-box transcription factor 21 (T-bet), which is the master regulator of effector T-cell
activation, is derived by stimulation of T-cell receptors. In this study, we focused on T-bet and …

Background It is important to identify biomarkers for triple-negative breast cancers (TNBCs).
Recently, pembrolizumab, an immune checkpoint inhibitor (ICI) for programmed cell death 1 …

Background/Aim: Abnormalities in the cyclin D1–CDK4/6 complex have been implicated in
breast cancer proliferation and resistance to treatment. Recently, new drugs have been …

Introduction PREDICT is a prognostication tool that calculates the potential benefit of various
postsurgical treatments on the overall survival (OS) of patients with nonmetastatic invasive …

Simple Summary A multigene panel test, known as comprehensive genomic profiling (CGP),
is now available in Japan for advanced cancer patients to identify suitable genotype-…

Simple Summary Triple-negative breast cancer (TNBC) is generally malignant and has a poor
prognosis. New biomarkers and therapeutic strategies are therefore needed. In this study, …

The role of the resection of primary tumour in stage IV breast cancer is unclear. Systemic
therapy is recommended to prolong the survival and improve the quality of life (QOL). However, …

Background/Aim: With advances in anti-HER2 treatment and improved prognoses of HER2-positive
breast cancer, the American Society of Clinical Oncology and the American Society …

Objectives: Non-surgical treatment is an acceptable approach for managing appendiceal
abscess in adults. However, it is only applicable for selected patients, and conversion to …