[HTML][HTML] Regulation of mitochondrial proliferation by PGC-1α induces cellular apoptosis in musculoskeletal malignancies

…, T Ueha, T Kawamoto, H Hara, M Toda, R Harada… - Scientific reports, 2014 - nature.com
A number of studies have reported that decreased mitochondrial numbers are linked with
neoplastic transformation and/or tumor progression, including resistance to apoptosis. …

[HTML][HTML] Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases)

H Hara, Y Sakai, T Kawamoto, N Fukase… - Journal of Bone …, 2021 - Elsevier
Background Skeletal related events due to metastatic bone tumors markedly affect the
activities of daily living (ADL) and quality of life (QOL) in cancer patients. We focused on …

Prognostic influence of the treatment approach for pulmonary metastasis in patients with soft tissue sarcoma

T Kawamoto, H Hara, M Morishita, N Fukase… - Clinical & Experimental …, 2020 - Springer
Soft tissue sarcomas (STSs) are rare heterogeneous malignancies of mesenchymal origin.
Pulmonary metastases develop in approximately 50% of the patients with high-grade STS, …

Quality of life and cost-utility of surgical treatment for patients with spinal metastases: prospective cohort study

…, M Ito, Y Kakiuchi, Y Takeoka, H Hara… - International …, 2017 - Springer
Purpose Palliative surgery for patients with spinal metastasis provides good clinical
outcomes. However, there have been few studies on quality of life (QOL) and cost-utility of this …

[HTML][HTML] AICAR induces mitochondrial apoptosis in human osteosarcoma cells through an AMPK-dependent pathway

M Morishita, T Kawamoto, H Hara… - International …, 2017 - spandidos-publications.com
The AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide
ribonucleotide (AICAR) modulates cellular energy metabolism, and promotes mitochondrial …

[HTML][HTML] Survival Rate after Palliative Surgery Alone for Symptomatic Spinal Metastases: A Prospective Cohort Study

…, Y Hiranaka, S Hayashi, Y Hoshino, H Hara… - Journal of Clinical …, 2022 - mdpi.com
The effect of spine surgery for symptomatic spinal metastases (SSM) on patient prognosis
remains unclear. This study aimed to reveal the prognosis of patients with SSM after spine …

[HTML][HTML] Verasense sensor-assisted total knee arthroplasty showed no difference in range of motion, reoperation rate or functional outcomes when compared to …

MP Sava, H Hara, L Alexandra, RW Hügli… - Knee Surgery, Sports …, 2023 - Springer
Purpose The aim of this systematic review was to investigate the clinical and functional
knee outcomes after Verasense sensor-assisted total knee arthroplasty (VA TKA), and to …

Prospective cohort study of performance status and activities of daily living after surgery for spinal metastasis

…, S Miyazaki, Y Terashima, M Ito, H Hara… - Clinical spine …, 2017 - journals.lww.com
Study Design: A prospective cohort study of performance status (PS) and activities of daily
living (ADL) in patients with spinal metastasis. Objective: To identify the effect of spinal surgery …

Reoxygenation using a novel CO2 therapy decreases the metastatic potential of osteosarcoma cells

R Harada, T Kawamoto, T Ueha, M Minoda… - Experimental cell …, 2013 - Elsevier
Osteosarcoma is the most common primary solid malignant bone tumor. Despite substantial
improvements in surgery and chemotherapy, metastasis remains a major cause of fatal …

[HTML][HTML] Transcutaneous Application of Carbon Dioxide (CO2) Induces Mitochondrial Apoptosis in Human Malignant Fibrous Histiocytoma In Vivo

…, K Kishimoto, H Hara, N Fukase, M Toda, R Harada… - PloS one, 2012 - journals.plos.org
Mitochondria play an essential role in cellular energy metabolism and apoptosis. Previous
studies have demonstrated that decreased mitochondrial biogenesis is associated with …