User profiles for HISAO IMAI

Hisao Imai

Department of Respiratory Medicine, Comprehensive Cancer Center, International Medical …
Verified email at gunma-u.ac.jp
Cited by 3908

CX3C-chemokine, fractalkine-enhanced adhesion of THP-1 cells to endothelial cells through integrin-dependent and-independent mechanisms

S Goda, T Imai, O Yoshie, O Yoneda… - The Journal of …, 2000 - journals.aai.org
Leukocyte adhesion and trafficking at the endothelium requires both cellular adhesion
molecules and chemotactic factors. A newly identified CX 3 C chemokine, fractalkine, expressed …

Fractalkine-mediated endothelial cell injury by NK cells

O Yoneda, T Imai, S Goda, H Inoue… - The Journal of …, 2000 - journals.aai.org
Endothelial cells (ECs) are primary targets of immunological attack, and their injury can lead
to vasculopathy and organ dysfunction in vascular leak syndrome and in rejection of …

Knockdown of oncogenic KRAS in non–small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy

…, L Girard, M Peyton, JE Larsen, H Imai… - Molecular cancer …, 2011 - AACR
Oncogenic KRAS is found in more than 25% of lung adenocarcinomas, the major histologic
subtype of non–small cell lung cancer (NSCLC), and is an important target for drug …

Prognostic impact of cancer cachexia in patients with advanced non-small cell lung cancer

…, T Oyakawa, Y Hisamatsu, T Tokito, H Imai… - Supportive Care in …, 2015 - Springer
Purpose Cancer cachexia (CC) is commonly seen in advanced lung cancer patients and
associated with poor prognosis. However, little is known about CC that develops during …

l‐type amino acid transporter 1 and CD98 expression in primary and metastatic sites of human neoplasms

K Kaira, N Oriuchi, H Imai, K Shimizu… - Cancer …, 2008 - Wiley Online Library
The significance of l‐type amino acid transporter (LAT) 1 expression remains unclear in the
metastatic process of human neoplasms, whereas experimental studies have demonstrated …

Inhibition of L-type amino acid transporter 1 has antitumor activity in non-small cell lung cancer

H Imai, K Kaira, N Oriuchi, K Shimizu… - Anticancer …, 2010 - ar.iiarjournals.org
Background: L-type amino acid transporter 1 (LAT1) is highly expressed in various human
neoplasms. Antitumor activity of inhibiting LAT1 was analyzed in non-small cell lung cancer (…

Oncogenic KRAS‐induced interleukin‐8 overexpression promotes cell growth and migration and contributes to aggressive phenotypes of non‐small cell lung cancer

N Sunaga, H Imai, K Shimizu… - … journal of cancer, 2012 - Wiley Online Library
The CXC chemokine interleukin‐8 (IL‐8) is an angiogenic growth factor that is overexpressed
in various cancers, including non‐small cell lung cancer (NSCLC). Previously, IL‐8 was …

Prognostic significance of L-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in stage I pulmonary adenocarcinoma

K Kaira, N Oriuchi, H Imai, K Shimizu, N Yanagitani… - Lung cancer, 2009 - Elsevier
BACKGROUND: The purpose of this study was to evaluate the prognostic value of l-type amino
acid transporter 1 (LAT1) and 4F2 heavy chain (CD98) expression in patients with stage I …

Fluorine-18-α-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: a clinicopathologic study

…, N Oriuchi, Y Otani, K Shimizu, S Tanaka, H Imai… - Clinical Cancer …, 2007 - AACR
Purpose: l-[3- 18 F]-α-Methyltyrosine ([ 18 F]FMT) is an amino acid tracer for positron emission
tomography (PET). We evaluated the diagnostic usefulness of [ 18 F]FMT PET in non–…

Vitamin D receptor gene polymorphism is associated with chronic periodontitis

…, Y Nosaka, T Kawamura, M Shinohara, M Ueda, H Imai… - Life Sciences, 2003 - Elsevier
Chronic periodontitis (CP) is caused by enhanced resorption of the alveolar bone supporting
the teeth and is associated with intraoral inflammation after infection with certain bacteria. …