The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non–small cell lung cancers

…, M Tabata, H Ueoka, M Tanimoto, H Date… - Clinical cancer …, 2005 - AACR
Purpose: Recent studies reported that clinical responsiveness to gefitinib was associated with
somatic mutation of epidermal growth factor receptor (EGFR) gene in non–small cell lung …

Clinicopathologic Features of Non-Small-Cell Lung Cancer with EML4ALK Fusion Gene

…, R Miyahara, K Okubo, T Manabe, H Date - Annals of surgical …, 2010 - Springer
Background A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4)
and the anaplastic lymphoma kinase (ALK) has recently been identified in non-small-cell …

[HTML][HTML] UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α

…, T Menju, M Sonobe, H Kakeya, M Toi, H Date… - Nature …, 2015 - nature.com
Hypoxia-inducible factor 1 (HIF-1) plays a role in tumour metastases; however, the genes
that activate HIF-1 and subsequently promote metastases have yet to be identified. Here we …

Japanese guideline for the treatment of idiopathic pulmonary fibrosis

…, K Takahashi, H Takahashi, Y Taguchi, H Date… - Respiratory …, 2018 - Elsevier
… Reports to date have almost all investigated the effect of pulmonary rehabilitation in
cases of moderate respiratory dysfunction with %FVC of 60–80%. The effect of pulmonary …

Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer

…, M Sonobe, S Nagai, K Okubo, H Wada, H Date… - Cancer, 2009 - Wiley Online Library
BACKGROUND: The authors elucidated particular chemokine receptors that are expressed
on lung cancer cells, as well as the clinical significance of the expression of these …

[HTML][HTML] Inhaled nitric oxide reduces human lung allograft dysfunction

H Date, AN Triantafillou, EP Trulock, MS Pohl… - The Journal of thoracic …, 1996 - Elsevier
Objective: Early severe graft dysfunction, as manifested by hypoxia and pulmonary hypertension,
occurs in 10% to 20% of lung transplant recipients. We retrospectively investigated …

Risk factors for local progression after percutaneous radiofrequency ablation of lung tumors: evaluation based on a preliminary review of 342 tumors

…, T Mukai, S Hase, T Iguchi, H Fujiwara, H Date… - Cancer, 2006 - Wiley Online Library
BACKGROUND. The purpose of the study was to retrospectively evaluate the risk factors for
local progression after percutaneous radiofrequency (RF) ablation of lung tumors. …

Presence of Epidermal Growth Factor Receptor Gene T790M Mutation as a Minor Clone in Non–Small Cell Lung Cancer

…, M Ouchida, K Aoe, M Aoe, K Kiura, N Shimizu, H Date - Cancer research, 2006 - AACR
The threonine-to-methionine substitution at amino acid position 790 (T790M) of the
epidermal growth factor receptor (EGFR) gene has been reported in progressing lesions after …

Pulmonary function, postoperative pain, and serum cytokine level after lobectomy: a comparison of VATS and conventional procedure

I Nagahiro, A Andou, M Aoe, Y Sano, H Date… - The Annals of thoracic …, 2001 - Elsevier
Background. Although lobectomy by the video-assisted thoracic surgical (VATS) approach
is assumed to be less invasive than lobectomy by the standard posterolateral thoracotomy (…

PIK3CA Mutations and Copy Number Gains in Human Lung Cancers

…, II Wistuba, KM Fong, H Lee, S Toyooka, H Date… - Cancer research, 2008 - AACR
We investigated the frequency and function of mutations and increased copy number of the
PIK3CA gene in lung cancers. PIK3CA mutations are one of the most common gene changes …