Tetraspanins CD9 and CD81 facilitate the fusion between gametes, myoblasts, or virus-infected
cells. Here, we investigated the role of these tetraspanins in the fusion of mononuclear …

Lipocalin-type prostaglandin D synthase is responsible for the biosynthesis of prostaglandin
D 2 in the central nervous system and the genital organs and is secreted into the …

Background: Although studies suggest that exercise training improves physical performance
and health-related quality of life (HRQOL) among elderly people, most of these studies …

The clinical efficacy of gefitinib, a tyrosine kinase inhibitor of epidermal growth factor
receptor (EGFR), on brain metastases (BMs) from non–small-cell lung cancer (NSCLC) was …

Background— Mutations of KCNJ2, the gene encoding the human inward rectifier potassium
channel Kir2.1, cause Andersen-Tawil syndrome (ATS), a disease exhibiting ventricular …

Aims Ryanodine receptor gene (RYR2) mutations are well known to cause catecholaminergic
polymorphic ventricular tachycardia (CPVT). Recently, RYR2 exon 3 deletion has been …

Aims CACNA1C mutations have been reported to cause LQTS type 8 (LQT8; Timothy
syndrome), which exhibits severe phenotypes, although the frequency of patients with LQT8 …

Efficient differentiation of human pluripotent stem cells (hPSCs) into neurons is paramount
for disease modeling, drug screening, and cell transplantation therapy in regenerative …

Small cell lung cancer (SCLC) invades locally and metastasizes distantly extremely early
when compared with nonsmall cell lung cancer (NSCLC). The underlying molecular …

Background: The genetic background of catecholaminergic polymorphic ventricular tachycardia
(CPVT) has been extensively investigated for the last decade in Western countries, but it …