Carbon ion radiotherapy: clinical experiences at National Institute of Radiological Science (NIRS)

…, A Hasegawa, H Imada, H Kiyohara… - Journal of radiation …, 2010 - academic.oup.com
In June 1994, the world's first clinical center offering carbon ion radiotherapy opened at the
National Institute of Radiological Science (NIRS), Japan. Among several types of ion species, …

Organ and brain crosstalk: The liver-brain axis in gastrointestinal, liver, and pancreatic diseases

Y Matsubara, H Kiyohara, T Teratani, Y Mikami… - …, 2022 - Elsevier
The liver is the largest organ in the human body and is responsible for the metabolism and
storage of the three principal nutrients: carbohydrates, fats, and proteins. In addition, the liver …

Transperineal ultrasound predicts endoscopic and histological healing in ulcerative colitis

…, M Matsubayashi, H Kiyohara… - Alimentary …, 2020 - Wiley Online Library
Background Transabdominal ultrasound is useful to assess inflammation in patients with
ulcerative colitis (UC); however, the assessment of the rectum is challenging and a barrier for …

In-room computed tomography–based brachytherapy for uterine cervical cancer: results of a 5-year retrospective study

…, K Murata, K Shibuya, H Kiyohara… - Journal of radiation …, 2017 - academic.oup.com
Herein, we investigate the long-term clinical outcomes for cervical cancer patients treated
with in-room computed tomography–based brachytherapy. Eighty patients with Stage IB1–IVA …

[HTML][HTML] Clinical efficacy and safety of oral Qing-Dai in patients with ulcerative colitis: a single-center open-label prospective study

S Sugimoto, M Naganuma, H Kiyohara, M Arai, K Ono… - Digestion, 1960 - karger.com
Background/Aims: Chinese herbal medicine Qing-Dai (also known as indigo naturalis) has
been used to treat various inflammatory conditions. However, not much has been studied …

The ulcerative colitis endoscopic index of severity is useful to predict medium-to long-term prognosis in ulcerative colitis patients with clinical remission

…, M Naganuma, S Sugimoto, H Kiyohara… - Journal of Crohn's …, 2016 - academic.oup.com
Background: The ulcerative colitis endoscopic index of severity [UCEIS] is a validated scoring
system. Nevertheless, few studies have investigated its usefulness in clinical settings. In …

[HTML][HTML] Significance of 5-aminosalicylic acid intolerance in the clinical management of ulcerative colitis

…, J Tsunoda, S Suzuki, I Mizushima, H Kiyohara… - Digestion, 2023 - karger.com
Hiroki KiyoharaHiroki Kiyohara was responsible for intellectual input and critically revised
the manuscript. Takanori Kanai provided supervision and gave final approval of the article. …

Vagus nerve-mediated intestinal immune regulation: therapeutic implications of inflammatory bowel diseases

Y Mikami, J Tsunoda, H Kiyohara… - International …, 2022 - academic.oup.com
The pathophysiology of inflammatory bowel diseases (IBDs) involves immunological,
genetic and environmental factors. Through its ability to sense environmental stimuli, the …

Carbon ion radiotherapy for sacral chordoma: a retrospective nationwide multicentre study in Japan

Y Demizu, R Imai, H Kiyohara, A Matsunobu… - Radiotherapy and …, 2021 - Elsevier
Background and purpose Usefulness of carbon ion radiotherapy (CIRT) for sacral chordoma
has been reported from single institutions. We conducted a retrospective nationwide …

[HTML][HTML] Toll-like receptor 7 agonist–induced dermatitis causes severe dextran sulfate sodium colitis by altering the gut microbiome and immune cells

H Kiyohara, T Sujino, T Teratani, K Miyamoto… - Cellular and Molecular …, 2019 - Elsevier
Background & Aims Psoriasis and inflammatory bowel disease (IBD) are both chronic
inflammatory diseases occurring in the skin and gut, respectively. It is well established that …