User profiles for HIDEKI MURAMATSU

Hideki Muramatsu

Verified email at med.nagoya-u.ac.jp
Cited by 4716

Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas

T Hida, Y Yatabe, H Achiwa, H Muramatsu, K Kozaki… - Cancer research, 1998 - AACR
Cyclooxygenase (COX)-2 expression was immunohistochemically examined in 59 human
lung cancers as well as in normal and premalignant lung specimens. In contrast to scattered …

The landscape of somatic mutations in Down syndrome–related myeloid disorders

…, N Shiba, K Chiba, H Tanaka, A Hama, H Muramatsu… - Nature …, 2013 - nature.com
Transient abnormal myelopoiesis (TAM) is a myeloid proliferation resembling acute
megakaryoblastic leukemia (AMKL), mostly affecting perinatal infants with Down syndrome. …

Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines

T Hida, K Kozaki, H Muramatsu, A Masuda… - Clinical Cancer …, 2000 - AACR
In recent years, a combination of two demographic phenomena, an increase in the number
of older people in the population and an increase in the incidence of lung cancer with age, …

Somatic SETBP1 mutations in myeloid malignancies

…, MA Sekeres, K Chiba, H Tanaka, H Muramatsu… - Nature …, 2013 - nature.com
Here we report whole-exome sequencing of individuals with various myeloid malignancies
and identify recurrent somatic mutations in SETBP1, consistent with a recent report on …

Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia

H Sakaguchi, Y Okuno, H Muramatsu, K Yoshida… - Nature …, 2013 - nature.com
Juvenile myelomonocytic leukemia (JMML) is an intractable pediatric leukemia with poor
prognosis 1 whose molecular pathogenesis is poorly understood, except for somatic or …

[HTML][HTML] Mutations of e3 ubiquitin ligase cbl family members constitute a novel common pathogenic lesion in myeloid malignancies

…, A Dunbar, R Tiu, J Huh, H Muramatsu… - Journal of clinical …, 2009 - ncbi.nlm.nih.gov
Purpose Acquired somatic uniparental disomy (UPD) is commonly observed in myelodysplastic
syndromes (MDS), myelodysplastic/myeloproliferative neoplasms (MDS/MPN), or …

[PDF][PDF] ACTN1 mutations cause congenital macrothrombocytopenia

…, Y Shiraishi, M Sanada, H Muramatsu… - The American Journal of …, 2013 - cell.com
Congenital macrothrombocytopenia (CMTP) is a heterogeneous group of rare platelet disorders
characterized by a congenital reduction of platelet counts and abnormally large platelets…

[PDF][PDF] Two aldehyde clearance systems are essential to prevent lethal formaldehyde accumulation in mice and humans

…, M Mori, Y Okamoto, Y Okuno, H Muramatsu… - Molecular cell, 2020 - cell.com
Reactive aldehydes arise as by-products of metabolism and are normally cleared by
multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes, …

Defective Epstein–Barr virus in chronic active infection and haematological malignancy

Y Okuno, T Murata, Y Sato, H Muramatsu, Y Ito… - Nature …, 2019 - nature.com
Epstein–Barr virus (EBV) infection is highly prevalent in humans and is implicated in various
diseases, including cancer 1 , 2 . Chronic active EBV infection (CAEBV) is an intractable …

Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis

…, A Pellagatti, K McGraw, H Muramatsu… - Blood, The Journal …, 2012 - ashpublications.org
Loss of heterozygosity affecting chromosome 7q is common in acute myeloid leukemia and
myelodysplastic syndromes, pointing toward the essential role of this region in disease …