Epithelial expression of YAP and TAZ is sequentially required in lung development

H Isago, A Mitani, Y Mikami, M Horie… - American Journal of …, 2020 - atsjournals.org
TAZ (transcriptional coactivator with PDZ-binding motif) and YAP (Yes-associated protein)
are key molecules of the Hippo pathway. Recent studies revealed that these molecules are …

Exosomal microRNA expression profiling in patients with lung adenocarcinoma-associated malignant pleural effusion

…, A Mitani, A Saito, T Ishimori, M Saito, H Isago… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Cytological analysis for diagnosing malignant pleural effusion associated
with lung adenocarcinoma (Ad-MPE) shows limited sensitivity and novel diagnostic …

Active mTOR in lung epithelium promotes epithelial–mesenchymal transition and enhances lung fibrosis

…, A Mitani, T Ishimori, N Miyashita, H Isago… - American Journal of …, 2020 - atsjournals.org
The mTOR pathway is one of the key signal cascades in the pathogenesis of idiopathic
pulmonary fibrosis. Previous studies have mainly focused on this pathway in the fibroblasts and/…

[HTML][HTML] Development of an advanced liquid chromatography–tandem mass spectrometry measurement system for simultaneous sphingolipid analysis

B Uranbileg, E Sakai, M Kubota, H Isago, M Sumitani… - Scientific Reports, 2024 - nature.com
Mass spectrometry-based lipidomics approaches offer valuable tools for the detection and
quantification of various lipid species, including sphingolipids. The present study aimed to …

The Japanese herbal (Kampo) medicine Hochuekkito attenuates lung inflammation in lung emphysema

H Isago, A Mitani, S Kohno, S Nagoshi… - Biological and …, 2021 - jstage.jst.go.jp
Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disorder. It often
causes weight loss, which is considered a poor prognostic factor. A Japanese herbal Kampo …

[HTML][HTML] Measurement of chest wall motion using a motion capture system with the one-pitch phase analysis method

H Tamiya, A Mitani, H Isago, T Ishimori, M Saito, T Jo… - Scientific Reports, 2021 - nature.com
Spirometry is a standard method for assessing lung function. However, its use is challenging
in some patients, and it has limitations such as risk of infection and inability to assess …

[HTML][HTML] Correlation between variant call accuracy and quality parameters in comprehensive cancer genomic profiling tests

H Isago, K Watanabe, Y Satoh, M Kurano - Practical Laboratory Medicine, 2024 - Elsevier
Background Comprehensive genomic profiling (CGP) tests have been widely utilized in
clinical practice. In this test, the variant list automatically output from the data analysis pipeline …

Understanding the modulations of glycero-lysophospholipids in an elastase-induced murine emphysema model

H Isago, B Uranbileg, A Mitani, M Kurano - Biochemical and Biophysical …, 2024 - Elsevier
Background Increasing evidence indicates that bioactive lipid mediators are involved in
chronic obstructive pulmonary disease (COPD) pathogenesis. Recently, glycero-…

Development of pulmonary artery aneurysms due to Behçet's disease and resolution after treatment

H Kage, Y Goto, Y Amano, K Makita, H Isago… - Internal …, 2016 - jstage.jst.go.jp
We herein describe a patient with Behçet’s disease in whom we followed the development
and resolution of pulmonary artery aneurysms. He presented with intermittent hemoptysis, …

[HTML][HTML] Successful treatment of pulmonary injury after nitrogen oxide exposure with corticosteroid therapy: A case report and review of the literature

Y Kido, A Mitani, H Isago, H Takeshima… - … medicine case reports, 2017 - Elsevier
Nitrogen oxides are representative chemicals of occupational and environmental exposure,
which can lead to fatal pulmonary injury. These oxides are also known to cause delayed …