FTY720 is a unique immunosuppressive agent that exerts its activity by inducing apoptosis
in lymphocytes. We conducted the present study to investigate the effects of FTY720 on …

Background. Initial ischemia/reperfusion injury occurring secondary to organ retrieval, storage,
and transplantation has been associated with late renal allograft deterioration and failure. …

Chronic rejection, the most important cause of long-term graft failure, is thought to result
from both alloantigen-dependent and -independent factors. To examine these influences, …

Blocking CD28-B7 T-cell costimulation by systemic administration of CTLA4Ig, a fusion protein
which binds B7 molecules on the surface of antigen-presenting cells, prevents rejection …

Functioning nephron mass has recently been implicated as a risk factor for development of
chronic “rejection” of kidney allografts. Reductions in nephron number below 50% may …

During the past decade, treatment strategies for patients with advanced prostate cancer
involving stage IV (T4N0M0, N1M0 or M1) hormone‐sensitive prostate cancer and recurrent …

Prostate cancer (PCa) is one of the common malignancies in male adults. Recent advances
in omics technology, especially in next-generation sequencing, have increased the …

Older organs represent an untapped potential to close the gap between demand and
supply in organ transplantation but are associated with age-specific responses to injury and …

The androgen receptor (AR) plays an essential role in prostate cancer, and suppression of
its signaling with androgen deprivation therapy (ADT) has been the mainstay of treatment for …

Although chronic rejection remains the most crucial cause of organ graft loss over the long
term, its etiology is not well defined. Early injury to graft endothelial cells caused by …