Molecular variants of fibronectin and laminin: structure, physiological occurrence and histopathological aspects

H Kosmehl, A Berndt, D Katenkamp - Virchows Archiv, 1996 - Springer
This review deals with biological and pathological aspects of various isoforms of the matrix
molecules fibronectin and laminin. They are generated by different molecular mechanisms: …

Diagnosis of oral squamous cell carcinoma and its precursor lesions

…, U Müller‐Richter, H Kosmehl… - JDDG: Journal der …, 2007 - Wiley Online Library
Improvement of survival rate and quality of life after treatment of oral squamous cell carcinoma
as well as cost reduction requires reliable early diagnosis of the tumor and its precursor …

Enhancement of the antitumor properties of interleukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix

…, A Berndt, S Ferrini, H Kosmehl… - Blood, The Journal …, 2002 - ashpublications.org
Angiogenic processes depend on the precise coordination of different cell types and a
complex exchange of signals, many of which derive from new specific components of the …

Selective targeted delivery of TNFα to tumor blood vessels

…, F Sassi, P Castellani, A Berndt, H Kosmehl… - Blood, 2003 - ashpublications.org
We sought to enhance the selective toxicity of tumor necrosis factor α (TNFα) to permit its
systemic use in cancer therapy. Because ligand-targeted therapeutics have proven successful …

Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice

F Nilsson, H Kosmehl, L Zardi, D Neri - Cancer research, 2001 - AACR
The selective thrombosis of tumor blood vessels, leading to the starvation and subsequent
death of tumor cells, is an attractive anticancer strategy. Here we report that a fusion protein, …

Artificial vascular implants from bacterial cellulose: preliminary results of small arterial substitutes

…, DO Klemm, F Kramer, D Koth, H Kosmehl… - Cellulose, 2009 - Springer
The biomaterial bacterial cellulose (BC) represents an innovative approach for overcoming
reconstructive problems associated with extended vascular diseases by providing small …

Synergistic therapeutic effects of a tumor targeting antibody fragment, fused to interleukin 12 and to tumor necrosis factor α

…, V Gafner, ME Villani, L Borsi, A Berndt, H Kosmehl… - Cancer research, 2003 - AACR
The potent antitumor activity of certain cytokines is often achieved at the expense of unacceptable
toxicity. One avenue to improve the therapeutic index of cytokines in cancer therapy …

The tumour-targeting human L19-IL2 immunocytokine: preclinical safety studies, phase I clinical trial in patients with solid tumours and expansion into patients with …

…, G Pecher, K Miller, A Berndt, H Kosmehl… - European journal of …, 2010 - Elsevier
BACKGROUND: L19-IL2, a tumour-targeting immunocytokine composed of the recombinant
human antibody fragment L19 (specific to the alternatively-spliced EDB domain of …

Engineered vascular‐targeting antibody‐interferon‐γ fusion protein for cancer therapy

…, D Grabulovski, A Berndt, H Kosmehl… - … journal of cancer, 2005 - Wiley Online Library
A number of cytokines are either approved drugs or are in advanced clinical trials, yet these
biopharmaceuticals do not typically localize efficiently in solid tumors and manifest their …

Cherubism–new hypotheses on pathogenesis and therapeutic consequences

…, JH Clement, V Beensen, H Peters, H Kosmehl - Journal of Cranio …, 2005 - Elsevier
AIMS: The hereditary occurrence of cherubism indicates a probable genetic aetiology: a
correlation with a mutation in the gene SH3BP2 has been demonstrated. A convincing concept …