Effects of biguanides on growth and glycolysis of bladder and colon cancer cells

MA Lea, H Kim - Anticancer research, 2018 - ar.iiarjournals.org
Background/ Aim: There is evidence that inhibitory effects of biguanides on oxidative
phosphorylation require uptake of biguanides into the mitochondria. In this study the action of two …

Uptake of biguanides in mitochondria appears to be related to increased glucose uptake and medium acidification but not necessarily related to inhibition of growth of …

MA Lea, H Kim, C desBordes - Cancer Research, 2018 - AACR
Biguanides including metformin have been used in the treatment of Type 2 diabetes and they
are under investigation as anti-cancer agents. Investigation on the mechanism of action of …