The immunosuppressant rapamycin interferes with G 1 -phase progression in lymphoid and
other cell types by inhibiting the function of the mammalian target of rapamycin (mTOR). …

The mammalian target of rapamycin (mTOR) has been shown to link growth factor signaling
and posttranscriptional control of translation of proteins that are frequently involved in cell …

Neuroblastomas (NBs) show complex patterns of genetic abnormalities, which may include
amplification of the MYCN gene, deletion of 1p, or a gain of DNA at 17q, the last being the …

Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we
studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and …

The number of obese patients has increased annually worldwide. Therefore, there is a
strong need to develop a new effective and safe anti-obesity drug. Miglitol is an alpha-…

This article reviews the current status of treatment for children with rhabdomyosarcoma,
according to the four risk groups. Low‐risk subgroup A: the Children's Oncology Group in the …

Duchenne muscular dystrophy (DMD) causes cognitive impairment in one third of the patients,
although the underlying mechanisms remain to be elucidated. Recent studies showed …

Rhabdomyosarcomas are a heterogeneous group of tumors with respect to their molecular
basis, degree of differentiation, histology, and clinical behavior. Because of the wide variation …

Presently there is no serum biomarker of rhabdomyosarcoma (RMS). Several studies have
shown that profiles of microRNA (miRNA) expression differ among tumor types. Here we …

Two distinct signaling pathways regulate the survival of interleukin-3 (IL-3)-dependent
hematopoietic progenitors. One originates from the membrane-proximal portion of the cytoplasmic …