IgG4-related disease is a newly recognized fibro-inflammatory condition characterized by
several features: a tendency to form tumefactive lesions in multiple sites; a characteristic …

The effects of vascular endothelial growth factor (VEGF) blockade on the vascular biology of
human tumors are not known. Here we show here that a single infusion of the VEGF-specific …

Hedgehog signalling—an essential pathway during embryonic pancreatic development, the
misregulation of which has been implicated in several forms of cancer—may also be an …

Purpose Chemotherapy before resection of hepatic colorectal metastases (CRM) may cause
hepatic injury and affect postoperative outcome. Patients and Methods Four hundred six …

Morphologic assessment of dysplasia in Barrett esophagus, despite limitations, remains the
basis of treatment. We rigorously tested modified 1988 criteria, assessing intraobserver and …

Hippo-Lats-Yorkie signaling regulates tissue overgrowth and tumorigenesis in Drosophila.
We show that the Mst1 and Mst2 protein kinases, the mammalian Hippo orthologs, are …

Owing to improvements in imaging techniques, cystic lesions of the pancreas are being
identified more often, even in patients who are asymptomatic. These lesions range from benign …

PURPOSE: The current American Joint Committee on Cancer (AJCC) staging system for
hepatocellular carcinoma (HCC) fails to stratify patients adequately with respect to prognosis. …

SMAD4 is inactivated in the majority of pancreatic ductal adenocarcinomas (PDAC) with
concurrent mutational inactivation of the INK4A/ARF tumor suppressor locus and activation of …

Vascular invasion and high histologic grade predict poor outcome after surgical resection or
liver transplantation for hepatocellular carcinoma (HCC). Despite the known association …