3511 Background: Preop CTRT is considered the standard of care in the management of
LARC. RT can induce antigen release from a low neoantigen-burden tumor (such as a …

GEO is a well-differentiated colon cancer cell line that coexpresses the epidermal growth
factor-like growth factors CRIPTO (CR), amphiregulin (AR), and transforming growth factor …

8-Chloro-cAMP (8-Cl-cAMP) is a novel agent that is able to inhibit the growth of a wide variety
of cancer cell types in vitro and in vivo and, at doses devoid of toxicity, to achieve plasma …

8-Chloro-cyclic AMP (8-Cl-cAMP) is a cAMP analogue that specifically down-regulates type
I protein kinase A, a signaling protein directly involved in cell proliferation and neoplastic …

Background The potential predictive role of programmed death-ligand-1 (PD-L1) expression
on tumor cells in the context of solid tumor treated with checkpoint inhibitors targeting the PD…

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…

Functional activation of growth factors and receptors of the epidermal growth factor receptor
(EGFR) family occurs in most epithelial-cell cancers, rendering EGFR a target for cancer …

Pancreatic cancer remains one of the most lethal of malignancies and a major health burden.
We performed whole-genome sequencing and copy number variation (CNV) analysis of …

Background Patients with a germline BRCA1 or BRCA2 mutation make up a small
subgroup of those with metastatic pancreatic cancer. The poly(adenosine diphosphate–ribose) …

The epidermal growth factor receptor (EGFR) autocrine pathway contributes to a number of
processes important to cancer development and progression, including cell proliferation, …