Uncoupling of platelet granule release and integrin activation suggests GPIIb/IIIa as a therapeutic target in COVID-19

LJ Weiss, M Drayss, G Manukjan, M Zeitlhöfler… - Blood …, 2023 - ashpublications.org
Thromboembolic events are frequent and life-threating complications of COVID-19 but are
also observed in patients with sepsis. Disseminated thrombosis can occur despite …

[PDF][PDF] RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes

T Heib, HM Hermanns, G Manukjan, M Englert… - Cell reports, 2021 - cell.com
Megakaryocytes (MKs), the precursors of blood platelets, are large, polyploid cells residing
mainly in the bone marrow. We have previously shown that balanced signaling of the Rho …

Acquired platelet GPVI receptor dysfunction in critically ill patients with sepsis

LJ Weiss, G Manukjan, A Pflug, N Winter… - Blood, The Journal …, 2021 - ashpublications.org
Glycoprotein VI (GPVI), the platelet immunoreceptor tyrosine activating motif (ITAM) receptor
for collagen, plays a striking role on vascular integrity in animal models of inflammation and …

Actin/microtubule crosstalk during platelet biogenesis in mice is critically regulated by Twinfilin1 and Cofilin1

…, S Beck, T Heib, K Aurbach, G Manukjan… - Blood …, 2020 - ashpublications.org
Rearrangements of the microtubule (MT) and actin cytoskeleton are pivotal for platelet
biogenesis. Hence, defects in actin- or MT-regulatory proteins are associated with platelet …

Impact of genetic variants on haematopoiesis in patients with thrombocytopenia absent radii (TAR) syndrome

G Manukjan, H Bösing, M Schmugge… - British journal of …, 2017 - Wiley Online Library
Thrombocytopenia absent radii ( TAR ) syndrome is clearly defined by the combination of
radial aplasia and reduced platelet counts. The genetics of TAR syndrome has recently been …

Diagnosis of platelet function disorders: a standardized, rational, and modular flow cytometric approach

O Andres, K Henning, G Strauß, A Pflug, G Manukjan… - Platelets, 2018 - Taylor & Francis
A high proportion of patients with mucocutaneous bleeding diathesis and suspected
inherited or acquired platelet disorder remain without diagnosis even after comprehensive …

[HTML][HTML] Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases

…, J Eilenberger, J Volz, G Manukjan… - Scientific reports, 2019 - nature.com
Zinc (Zn 2+ ) can modulate platelet and coagulation activation pathways, including fibrin
formation. Here, we studied the (patho)physiological consequences of abnormal platelet Zn 2+ …

Pivotal role of PDK1 in megakaryocyte cytoskeletal dynamics and polarization during platelet biogenesis

…, K Aurbach, MC Manke, G Manukjan… - Blood, The Journal …, 2019 - ashpublications.org
During thrombopoiesis, megakaryocytes (MKs) form proplatelets within the bone marrow (BM)
and release platelets into BM sinusoids. Phosphoinositide-dependent protein kinase-1 (…

G6b-B regulates an essential step in megakaryocyte maturation

IC Becker, Z Nagy, G Manukjan… - Blood …, 2022 - ashpublications.org
G6b-B is a megakaryocyte lineage-specific immunoreceptor tyrosine-based inhibition motif–containing
receptor, essential for platelet homeostasis. Mice with a genomic deletion of the …

[HTML][HTML] Newborn screening for aromatic l-amino acid decarboxylase deficiency–Strategies, results, and implication for prevalence calculations

…, JG Okun, D Kohlmüller, G Manukjan… - Molecular Genetics and …, 2024 - Elsevier
Background Aromatic l-amino acid decarboxylase deficiency (AADCD) is a rare, autosomal-recessive
neurometabolic disorder caused by variants in dopa decarboxylase (DDC) gene, …