HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer

K Kim, I Jutooru, G Chadalapaka, G Johnson, J Frank… - Oncogene, 2013 - nature.com
HOTAIR is a long intervening non-coding RNA (lincRNA) that associates with the Polycomb
Repressive Complex 2 (PRC2) and overexpression is correlated with poor survival for breast…

[HTML][HTML] Inhibition of NFκB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation

I Jutooru, G Chadalapaka, P Lei, S Safe - Journal of Biological Chemistry, 2010 - ASBMB
Curcumin activates diverse anticancer activities that lead to inhibition of cancer cell and tumor
growth, induction of apoptosis, and antiangiogenic responses. In this study, we observed …

Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer

K Kim, G Chadalapaka, SO Lee, D Yamada… - Oncogene, 2012 - nature.com
The human POK family members are transcription factors with a POZ domain and zinc-fingers
that act primarily as transcriptional repressors. Several members of this family are involved …

Curcumin decreases specificity protein expression in bladder cancer cells

G Chadalapaka, I Jutooru, S Chintharlapalli… - Cancer research, 2008 - AACR
Curcumin is the active component of tumeric, and this polyphenolic compound has been
extensively investigated as an anticancer drug that modulates multiple pathways and genes. In …

[HTML][HTML] The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration

Y Cheng, I Jutooru, G Chadalapaka, JC Corton… - Oncotarget, 2015 - ncbi.nlm.nih.gov
HOTTIP is a long non-coding RNA (lncRNA) transcribed from the 5′ tip of the HOXA locus
and is associated with the polycomb repressor complex 2 (PRC2) and WD repeat containing …

[HTML][HTML] Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors

S Pathi, I Jutooru, G Chadalapaka, V Nair, SO Lee… - PloS one, 2012 - journals.plos.org
Acetylsalicylic acid (aspirin) is highly effective for treating colon cancer patients postdiagnosis;
however, the mechanisms of action of aspirin in colon cancer are not well defined. Aspirin …

Oncogenic microRNA‐27a is a target for anticancer agent methyl 2‐cyano‐3, 11‐dioxo‐18β‐olean‐1, 12‐dien‐30‐oate in colon cancer cells

…, I Jutooru, G Chadalapaka… - … journal of cancer, 2009 - Wiley Online Library
Methyl 2‐cyano‐3,11‐dioxo‐18β‐olean‐1,12‐dien‐30‐oate (CDODA‐Me) is a synthetic
derivative of glycyrrhetinic acid, a triterpenoid phytochemical found in licorice extracts. CDODA‐…

GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway

SS Pathi, I Jutooru, G Chadalapaka, S Sreevalsan… - Molecular Cancer …, 2011 - AACR
Ethyl 2-((2,3-bis(nitrooxy)propyl)disulfanyl)benzoate (GT-094) is a novel nitric oxide (NO)
chimera containing an nonsteroidal anti-inflammatory drug (NSAID) and NO moieties and also …

Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents

I Jutooru, AS Guthrie, G Chadalapaka… - … and cellular biology, 2014 - Taylor & Francis
Reactive oxygen species (ROS)-inducing anticancer agents such as phenethylisothiocyanate
(PEITC) activate stress pathways for killing cancer cells. Here we demonstrate that PEITC-…

Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells

G Chadalapaka, I Jutooru, R Burghardt, S Safe - Molecular cancer research, 2010 - AACR
The epidermal growth factor receptor (EGFR) is an important chemotherapeutic target for
tyrosine kinase inhibitors and antibodies that block the extracellular domain of EGFR. Betulinic …