Neuroprotection promoted by guanosine depends on glutamine synthetase and glutamate transporters activity in hippocampal slices subjected to oxygen/glucose …
…, WC Martins, DT Thomaz, V Coelho, GG Poluceno… - Neurotoxicity …, 2016 - Springer
Guanosine (GUO) has been shown to act as a neuroprotective agent against glutamatergic
excitotoxicity by increasing glutamate uptake and decreasing its release. In this study, a …
excitotoxicity by increasing glutamate uptake and decreasing its release. In this study, a …
Anti-cancer effects of fucoxanthin on human glioblastoma cell line
…, KA Oliveira, RG Lopes, GG Poluceno… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: Glioblastomas (GBMs) are the most malignant primary brain tumor. New
treatment strategies against the disease are urgently needed, as therapies are not completely …
treatment strategies against the disease are urgently needed, as therapies are not completely …
Long-term neurobehavioral consequences of a single ketamine neonatal exposure in rats: effects on cellular viability and glutamate transport in frontal cortex and …
…, LC Constantino, AP Costa, GG Poluceno… - Neurotoxicity …, 2018 - Springer
The neonatal exposure to general anesthetics has been associated with neuronal
apoptosis and dendritic spines morphologic changes in the developing brain. Ketamine, a …
apoptosis and dendritic spines morphologic changes in the developing brain. Ketamine, a …
Neonatal isoflurane exposure in rats impairs short-term memory, cell viability, and glutamate uptake in slices of the Frontal Cerebral cortex, but not the Hippocampus …
LF de Oliveira, GG Poluceno, TB Sampaio… - Neurotoxicity …, 2022 - Springer
Neonatal exposure to general anesthetics has been associated with neurotoxicity and
morphologic changes in the developing brain. Isoflurane is a volatile anesthetic widely used in …
morphologic changes in the developing brain. Isoflurane is a volatile anesthetic widely used in …
[PDF][PDF] Guanosina e canais de potássio (BK): efeitos sobre a toxicidade glutamatérgica
GG Poluceno - 2016 - core.ac.uk
O glutamato é o neurotransmissor excitatório responsável por processos como memória e
aprendizagem. Porém, quando em excesso na fenda sináptica, o glutamato se torna tóxico, …
aprendizagem. Porém, quando em excesso na fenda sináptica, o glutamato se torna tóxico, …
[HTML][HTML] Ketamine-induced apoptosis in the mouse cerebral cortex follows similar characteristic of physiological apoptosis and can be regulated by neuronal activity
Q Wang, F Shen, R Zou, J Zheng, X Yu, Y Wang - Molecular Brain, 2017 - Springer
The effects of general anesthetics on inducing neuronal apoptosis during early brain development
are well-documented. However, since physiological apoptosis also occurs during this …
are well-documented. However, since physiological apoptosis also occurs during this …
[CITATION][C] Avaliação dos efeitos do nucleosídeo guanosina e da ativação farmacológica de canais de potássio (BK) em um modelo de isquemia cerebral in vitro
GG Poluceno - 2019
NANOCOMPLEXO DE GUANOSINA-ESCALENO: DESENVOLVIMENTO E AVALIAÇÃO IN VITRO DO PERFIL DE SEGURANÇA E EFICÁCIA NEUROPROTETORA
BC Guerino - 2020 - bdtd.ibict.br
Currently, it is sought to develop new pharmacological therapies for the treatment of diseases
that affect the Central Nervous System, often with irreversible sequelae, such as cerebral …
that affect the Central Nervous System, often with irreversible sequelae, such as cerebral …