Combining whole genome amplification (WGA) methods with novel laser-based microdissection
techniques has made it possible to exploit recent progress in molecular knowledge of …

PURPOSE Epigenetic alterations such as DNA methylation and histone modifications play
important roles in carcinogenesis. It was reported that global histone modification patterns are …

OBJECTIVES Sclerosing cholangitis in critically ill patients (SC-CIP) is a newly described
entity of severe biliary disease with progression to liver cirrhosis. The mechanisms leading to …

The cellular uptake and subcellular localization of indocyanine green (ICG; absorption band
700– 850 nm), and cell survival and ultrastructural changes following ICG-mediated …

Background The pathogenesis of fistulae in Crohn's disease (CD) patients is barely
understood. We recently showed that more than two-thirds of CD fistulae are covered with flat, …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are well-known cancer preventives, which
have been largely attributed to their antiproliferative and apoptosis-inducing activities. In this …

CD137 (ILA/4‐1BB) is a member of the tumor necrosis factor receptor family and regulates
activation, proliferation and programmed cell death in T lymphocytes. Here we show the …

AP-2 has been characterized previously as a unique 52×10 3 M r transcription activator
encoded by a single gene that is expressed in a restricted pattern during embryonic …

Purpose : We determined whether the sensitivity of detecting dysplasia or early bladder cancer
can be improved by 5-aminolevulinic acid induced porphyrin fluorescence. Materials and …

Background The prognostic value of CK20, Ki-67, and p53 has been investigated for non–muscle-invasive
urothelial bladder cancers but not for the distinct and clinically challenging …