[HTML][HTML] Reversing melanoma cross-resistance to BRAF and MEK inhibitors by co-targeting the AKT/mTOR pathway
Background The sustained clinical activity of the BRAF inhibitor vemurafenib (PLX4032/RG7204)
in patients with BRAF V600 mutant melanoma is limited primarily by the development …
in patients with BRAF V600 mutant melanoma is limited primarily by the development …
[HTML][HTML] Differential sensitivity of melanoma cell lines with BRAF V600E mutation to the specific Raf inhibitor PLX4032
…, JG Barretina, SM Kehoe, N Attar, E von Euw… - Journal of translational …, 2010 - Springer
Blocking oncogenic signaling induced by the BRAF V600E mutation is a promising approach
for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf …
for melanoma treatment. We tested the anti-tumor effects of a specific inhibitor of Raf …
MITF drives endolysosomal biogenesis and potentiates Wnt signaling in melanoma cells
…, HW Chen, TG Graeber, E von Euw… - Proceedings of the …, 2015 - National Acad Sciences
Canonical Wnt signaling plays an important role in development and disease, regulating
transcription of target genes and stabilizing many proteins phosphorylated by glycogen …
transcription of target genes and stabilizing many proteins phosphorylated by glycogen …
[HTML][HTML] WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors
About half of all melanomas harbor a mutation that results in a constitutively active BRAF
kinase mutant (BRAF V600E/K ) that can be selectively inhibited by targeted BRAF inhibitors (…
kinase mutant (BRAF V600E/K ) that can be selectively inhibited by targeted BRAF inhibitors (…
[PDF][PDF] Characterization of human cancer cell lines by reverse-phase protein arrays
…, W Deng, YNV Gopal, G Chen, EM von Euw… - Cancer cell, 2017 - cell.com
Cancer cell lines are major model systems for mechanistic investigation and drug
development. However, protein expression data linked to high-quality DNA, RNA, and drug-screening …
development. However, protein expression data linked to high-quality DNA, RNA, and drug-screening …
[HTML][HTML] CTLA4 blockade increases Th17 cells in patients with metastatic melanoma
E von Euw, T Chodon, N Attar, J Jalil, RC Koya… - Journal of translational …, 2009 - Springer
Background Th17 cells are CD4+ cells that produce interleukin 17 (IL-17) and are potent
inducers of tissue inflammation and autoimmunity. We studied the levels of this T cell subset in …
inducers of tissue inflammation and autoimmunity. We studied the levels of this T cell subset in …
Targeting PI3K/mTOR overcomes resistance to HER2-targeted therapy independent of feedback activation of AKT
NA O'Brien, K McDonald, L Tong, E von Euw… - Clinical Cancer …, 2014 - AACR
Purpose: Altered PI3K/mTOR signaling is implicated in the pathogenesis of a number of
breast cancers, including those resistant to hormonal and HER2-targeted therapies. …
breast cancers, including those resistant to hormonal and HER2-targeted therapies. …
Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer
…, S Pitts, F Kabbinavar, C Patel, E von Euw… - Journal of cancer …, 2014 - Springer
Objectives Dichloroacetate (DCA) is a highly bioavailable small molecule that inhibits
pyruvate dehydrogenase kinase, promoting glucose oxidation and reversing the glycolytic …
pyruvate dehydrogenase kinase, promoting glucose oxidation and reversing the glycolytic …
Human leukocyte antigen-E protein is overexpressed in primary human colorectal cancer
…, M Bianchini, EM Von Euw… - International …, 2008 - spandidos-publications.com
HLA-E is a non-classical MHC molecule whose expression by tumour cells has been
recently reported in several human cancer types. We studied HLA-E expression in colorectal …
recently reported in several human cancer types. We studied HLA-E expression in colorectal …
Extracellular acidosis triggers the maturation of human dendritic cells and the production of IL-12
D Martínez, M Vermeulen, E von Euw… - The Journal of …, 2007 - journals.aai.org
Although the development of an acidic tissue environment or acidosis is a hallmark of
inflammatory processes, few studies analyze the effect of extracellular pH on immune cells. We …
inflammatory processes, few studies analyze the effect of extracellular pH on immune cells. We …