User profiles for DUONG L. LE

Le T. Duong

Merck Research Laboratories
Verified email at merck.com
Cited by 9909

Integrins and signaling in osteoclast function

LT Duong, P Lakkakorpi, I Nakamura, GA Rodan - Matrix Biology, 2000 - Elsevier
Integrins are heterodimeric adhesion receptors that mediate cell–matrix and cell–cell
interactions. Osteoclasts highly express the αvβ3 integrin, which binds to a variety of extracellular …

Hepatic hydrothorax

K Baikati, DL Le, II Jabbour, S Singhal… - American Journal of …, 2014 - journals.lww.com
Hepatic hydrothorax is defined as a pleural effusion in patients with liver cirrhosis in the
absence of cardiopulmonary disease. The estimated prevalence among patients with liver …

Radiation-associated cardiac injury

R Eldabaje, DL Le, W Huang, LX Yang - Anticancer Research, 2015 - ar.iiarjournals.org
Chest radiotherapy continues to play an important role in the treatment of breast cancer,
Hodgkin's lymphoma, and other malignancies. Subsequent cardiac injury has been described …

Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

…, Y Zhuo, GA Wesolowski, GA Rodan, LT Duong - Bone, 2006 - Elsevier
Osteoarthritis (OA) is a chronic joint disease characterized by cartilage destruction,
subchondral bone sclerosis, and osteophyte formation. Subchondral bone stiffness has been …

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

…, B Yu, W Chang, T Qiu, M Pickarski, LT Duong… - Nature medicine, 2014 - nature.com
… PDGF-BB concentrations were significantly increased in bone marrow of OVX mice treated
with either PDGF-BB or L-235, but increased only in peripheral blood after treatment with L-…

The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat …

…, J Destefano, GA Rodan, LT Duong - … : Official Journal of …, 2004 - Wiley Online Library
Objective It has been suggested that subchondral bone remodeling plays a role in the
progression of osteoarthritis (OA). To test this hypothesis, we characterized the changes in the rat …

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

…, W Cromlish, S Desmarais, LT Duong… - Bioorganic & medicinal …, 2008 - Elsevier
… Our initial proof-of-concept compound, L-006235, was highly selective over cathepsins B,
L, and S in enzyme assays and had good pharmacokinetics. However more detailed studies …

Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial

…, OT Le, LTK Tran, CD Duong, DV Kieu, N Le… - The Lancet …, 2020 - thelancet.com
Background Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment
oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine …

Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells

E Jimi, I Nakamura, LT Duong, T Ikebe… - Experimental cell …, 1999 - Elsevier
Interleukin-1 (IL-1) is one of the most potent bone-resorbing factors involved in bone loss
associated with inflammation. We previously reported that IL-1 prolonged the survival of …

PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha (v) beta3 integrin, and phosphorylated by src kinase.

LT Duong, PT Lakkakorpi, I Nakamura… - The Journal of …, 1998 - Am Soc Clin Investig
Osteoclast activation is initiated by adhesion to the bone surface, followed by cytoskeletal
rearrangement, the formation of the sealing zone, and a polarized ruffled membrane. This …