S-nitrosylation of Drp1 mediates β-amyloid-related mitochondrial fission and neuronal injury

DH Cho, T Nakamura, J Fang, P Cieplak, A Godzik… - Science, 2009 - science.org
Mitochondria continuously undergo two opposing processes, fission and fusion. The
disruption of this dynamic equilibrium may herald cell injury or death and may contribute to …

Mitochondrial dynamics in cell death and neurodegeneration

DH Cho, T Nakamura, SA Lipton - Cellular and Molecular Life Sciences, 2010 - Springer
Mitochondria are highly dynamic organelles that continuously undergo two opposite processes,
fission and fusion. Mitochondrial dynamics influence not only mitochondrial morphology, …

[HTML][HTML] Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death

…, YK Kwon, HJ Lee, JIL Jun, HN Woo, DH Cho… - Journal of Biological …, 2005 - ASBMB
Autophagic cell death is characterized by the accumulation of vacuoles in physiological and
pathological conditions. However, its molecular event is unknown. Here, we show that Atg5, …

Caspase-mediated cleavage of ATG6/Beclin-1 links apoptosis to autophagy in HeLa cells

DH Cho, YK Jo, JJ Hwang, YM Lee, SA Roh, JC Kim - Cancer letters, 2009 - Elsevier
Autophagy is a catabolic process involved in cell death and in cell protective mechanism.
Autophagic cell death is differentiated from apoptosis by the presence of double or multiple-…

S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease

J Fang, T Nakamura, DH Cho, Z Gu… - Proceedings of the …, 2007 - National Acad Sciences
Peroxiredoxins (Prx), a family of peroxidases that reduce intracellular peroxides with the
thioredoxin system as the electron donor, are highly expressed in various cellular compartments…

Inhibition of Drp1 ameliorates synaptic depression, Aβ deposition, and cognitive impairment in an Alzheimer's disease model

…, J Kim, JW Han, JY Koh, DH Cho… - Journal of …, 2017 - Soc Neuroscience
Excessive mitochondrial fission is a prominent early event and contributes to mitochondrial
dysfunction, synaptic failure, and neuronal cell death in the progression of Alzheimer's …

Transcriptional regulation of mammalian autophagy at a glance

J Füllgrabe, G Ghislat, DH Cho… - Journal of cell …, 2016 - journals.biologists.com
Macroautophagy, hereafter referred to as autophagy, is a catabolic process that results in
the lysosomal degradation of cytoplasmic contents ranging from abnormal proteins to …

BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production

…, YS Kim, DE Kim, JS Lee, JH Song, HG Kim, DH Cho… - Autophagy, 2013 - Taylor & Francis
We screened a chemical library in MCF-7 cells stably expressing green fluorescent protein (GFP)-conjugated
microtubule-associated protein 1 light chain 3 (LC3) (GFP-LC3-MCF-7) …

[HTML][HTML] A nineteen gene-based risk score classifier predicts prognosis of colorectal cancer patients

SK Kim, SY Kim, JH Kim, SA Roh, DH Cho, YS Kim… - Molecular …, 2014 - Elsevier
Colorectal cancer (CRC) patients frequently experience disease recurrence and distant
metastasis. This study aimed to identify prognostic indicators, including individual responses to …

S-nitrosylation of Drp1 links excessive mitochondrial fission to neuronal injury in neurodegeneration

T Nakamura, P Cieplak, DH Cho, A Godzik, SA Lipton - Mitochondrion, 2010 - Elsevier
Neurons are known to use large amounts of energy for their normal function and activity. In
order to meet this demand, mitochondrial fission, fusion, and movement events (…