The vasculature of solid tumors is fundamentally different from that of normal vasculature
and offers a unique target for anti-cancer therapy. Direct vascular-targeting with Tumor-…

BACKGROUND Tumor endothelium represents a valuable target for cancer therapy. The
vasculature plays a critical role in the survival and continued growth of solid tumor masses; in …

The therapeutic potential of targeting the tumor vascular supply is now widely recognized.
Intense research and development activity has resulted in a variety of investigational agents, a …

Vascular-disrupting strategies impair a tumor's blood vessel network, which is essential for
tumor progression and metastasis. Vascular-disrupting agents (VDAs) cause a rapid and …

A functional vascular supply is critical for the continued growth and development of solid
tumors. It also plays a major role in metastatic spread of tumor cells. This importance has led to …

Proteolytic enzymes may serve as promising targets for novel therapeutic treatment strategies
seeking to impede cancer progression and metastasis. One such enzyme is cathepsin L (…

Background Previous studies have hypothesized that tumor blood flow may be elevated or
reduced during exercise, which could impact the tumor microenvironment. However, to date …

The tumor microenvironment is increasingly recognized as a major factor influencing the
success of therapeutic treatments and has become a key focus for cancer research. The …

Purpose : We identified a discrete population of stem cell-like tumor cells expressing 5 essential
transcription factors required to reprogram pluripotency in prostate tumor cell lines and …

BACKGROUND: Silencing of the viral CMV immediate early enhancer promoter can be a
problem in certain cell types when engineering stable cell lines. MATERIALS AND METHODS: …